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Article
Suprastin (Chloropyramine) Causes Proarrhythmic Deterioration of Excitation Conduction, Depolarization and Potentiates Adrenergic Automaticity in the Pulmonary Veins Myocardium
A number of pharmacological drugs have side effects that contribute to the occurrence of atrial fibrillation, the most common type of cardiac rhythm disorders. The clinical use of antihistamines is widespread;...
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Article
The Influence of Probenecid on the Proarrhythmic Effects of the Activation of α-1-adrenoceptor in the Atrioventricular Node of the Rat Heart
The cardiac tissue contains not only beta-type adrenergic receptors (ARs) but also alpha-type ARs (α-ARs). Both types of ARs play a significant role in the regulation of the electrophysiology of cardiomyocytes...
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Article
α1-Adrenergic Receptors Control the Activity of Sinoatrial Node by Modulating Transmembrane Transport of Chloride Anions
Norepinephrine (NE), which is released by sympathetic nerve endings, causes an increase in the frequency of spontaneous action potentials in the pacemaker cardiomyocytes of the sinoatrial node (SAN) of the hea...
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Article
Epulmonary Arterial Hypertension Attenuates Vasoconstrictor Responses Caused by Activation of Alpha-1-Adrenoreceptors in the Systemic Circulation
Pulmonary arterial hypertension (PAH) accompanied by an arterial pressure increase in the pulmonary circulation, remodeling of pulmonary arteries and a change in its sensitivity to regulatory factors; PAH is a...
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Article
The Dependence of the Electrophysiological Effects of Class III Antiarrhythmic Drug Refralon on the Frequency of Myocardium Activation
We studied the frequency dependence of the effects of the novel Russian class III antiarrhythmic drug refralon on the duration of action potentials (AP) in rabbit ventricular myocardium. The absence of an inve...
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Article
Open AccessErratum to: Screening of Medicinal Compounds in Blood by Atmospheric Pressure Laser Plasma Ionization Mass Spectrometry
An Erratum to this paper has been published: https://doi.org/10.1134/S1061934822370018
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Article
Open AccessScreening of Medicinal Compounds in Blood by Atmospheric Pressure Laser Plasma Ionization Mass Spectrometry
We proposed a procedure for screening drug compounds by high-resolution mass spectrometry with atmospheric pressure laser plasma ionization (APLPI). The analytical performance of the method was studied on exam...
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Article
The Molecular and Cellular Mechanisms of Heart Pacemaker Development in Vertebrates
A small group of specialized myocardial cells constitutes a natural dominant heart pacemaker in the so-called sinoatrial node (SAN). The SAN determines proper heart automaticity throughout life in animals, inc...
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Article
Changes in Electrophysiological Features of Rats’ Working Atrial Myocardium after Its Lipotransfection with MicroRNAs miR-1-3p, miR-153-3p, or miR-133a-3p
MicroRNA is a small, single-stranded nucleotide sequence, which can regulate gene expression at the posttranscriptional level. To date, it is known that some microRNAs play an important role in physiology and ...
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Article
The local repolarization heterogeneity in the murine pulmonary veins myocardium contributes to the spatial distribution of the adrenergically induced ectopic foci
An atrial tachyarrhythmias is predominantly triggered by a proarrhythmic activity originate from the pulmonary veins (PV) myocardial sleeves; sympathetic or adrenergic stimulation facilitates PV proarrhythmia....
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Article
Hypothermia-Induced Postrepolarization Refractoriness Is the Reason of the Atrial Myocardium Tolerance to the Bioelectrical Activity Disorders in the Hibernating and Active Ground Squirrel Citellus undulatus
The electrophysiological mechanism of the atrial myocardium resistance to the cold-induced arrhythmias was studied in the hibernating ground squirrel Citellus undulatus. The atrial action potentials (APs) and ref...
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Article
Supraventricular Myocardium in the Heart of the B6CBAF1 Mural Strain Reveals Genetically Determined Arrhythmogenic Properties due to Ectopic Automaticity and Triggered Activity
A significant amount of studies are aimed at investigating the mechanisms of occurrence and ways to prevent supraventricular arrhythmias, in particular, atrial fibrillation. Its occurrence in most cases is ass...
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Article
Extracellular Diadenosine Tetraphosphate Suppresses Ectopic Proarrhythmicity in the Myocardial Tissue of the Pulmonary Veins in Adult but not in Neonatal Rats
Diadenosine tetraphosphate (Ap4A) belongs to a group of endogenous purine compounds that have recently been considered as new neurotransmitters or cotransmitters in the autonomic nervous system. It has been sh...
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Article
Effects of Extracellular Diadenosine Tetraphosphate on Action Potentials in the Atrial and Ventricular Myocardium of the Rat Heart during Early Postnatal Ontogenesis
Diadenosine tetraphosphate (AP4A) belongs to a wide group of naturally derived endogenous purine compounds that have recently been considered as new neurotransmitters in the autonomic nervous system. It has be...
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Article
β-Adrenergic stimulation induces pro-arrhythmic activity in the caval vein myocardial tissue
Electrical activity of the right superior vena cava (SVC) is considered as a source of the atrial fibrillation. We have shown that bioelectrical properties of the SVC myocardium differ from those of the workin...
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Article
The role of cytoplasmic calcium in the regulation of the resting potential in the pulmonary veins myocardium in rats and mice
We have demonstrated the phenomenon of Са2+-induced hyperpolarization in the myocardium of pulmonary veins (PVs) in rats. An increase in cytoplasmic calcium [Са2+] i was shown t...
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Article
Evaluation of the length constant in the atrial myocardium and pulmonary vein myocardium in mammals
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Article
Inotropic Effects of Gaseous Transmitters in Isolated Rat Heart Preparation
We studied the effects of carbon monoxide and sodium hydrosulfide, hydrogen sulfide donor, on contractile activity of the left ventricle in Langendorf-perfused isolated rat heart. Carbon monoxide 5×10−5 M signifi...
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Article
Cholinergic regulation of body-wall muscle contraction of the ascidian Styela rustica (Linnaeus, 1767)
The regulation of body-wall muscle contraction in the ascidian Styela rustica was studied. Acetylcholine (ACh, 1–10 μM) induced a significant contraction of isolated muscle strips. The ACh-induced contractile res...
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Article
Estimate of inhomogeneous line broadening in steady-state magnetic resonance
We have established relationships between the experimental and theoretical absorption and dispersion line parameters for steady-state magnetic resonance, allowing us to determine both the field characteristics...
