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Article
Calcium-Activated Chloride Channels: The Role of Potassium Ions
Using the patch–clamp method in the whole-cell configuration, it was shown that external potassium ions play an important role in the regulation of calcium-activated chloride currents. A clear dependence of th...
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Article
Synthesis of New Conjugates of Edaravone and 1-Aminoadamantanes and Their Interaction with NMDA Receptors in Rats
New adamantane-containing derivatives of edaravone, one of two drugs used to treat amyotrophic lateral sclerosis, were synthesized. The pyrazolone ring and adamantane moiety in the new edaravone derivatives we...
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Article
Non-Newtonian Flow on Homogeneous-Heterogeneous Pore-Scale Reactive Transport: A Computational Analysis
This study presents a pore-scale model of a complex homogeneous-heterogeneous reaction. It is based on the Stokes equations, convection-diffusion-reaction equations, and Robin boundary conditions. The fluid is...
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Article
New Hybrid Structures Based on Memanthine and Edaravone Molecules
New hybrid structures based on memantine and edaravone molecules, in which the pyrazolone ring and adamantane fragments are linked by an alkyl linker, were synthesized. It was found that, in addition to the ab...
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Article
Chromian Tourmaline and Cr–Sb–W-Bearing Rutile of the Kamennoozerskoe Chromitite Occurrence, Central Urals, Russia
Tourmaline, rutile, and associated minerals from veinlets cutting chromitites are characteristic of the Kamennoozerskoe occurrence belonging to the Shabrovskii district in the Central Urals. Tourmaline belongs...
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Article
Scrap Deficit Problem at the Amurstal Metallurgical Plant and Search for Alternatives to Substitute It
The Amurstal plant is the only metallurgical plant in the Far East that produces steel using electric steelmaking technology with further conversion into rolled section steel. The construction of the plant sta...
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Article
Modification of phenothiazine and carbazole derivatives with trifluoromethyl-containing 1,3,5-oxadiazines and imidazolidinediones
Modification of phenothiazine and carbazole derivatives with trifluoromethyl-containing 1,3,5-oxadiazines and imidazolidinediones based on the copper(I)-catalyzed alkyne-azide 1,3-cycloaddition was carried out.
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Article
Role of Potassium Ions in Regulation of Calcium-Activated Chloride Channels
Using the patch-clamp method in the whole cell configuration, it was shown that external potassium ions play an important role in the regulation of calcium-activated chloride channels (CaCCs). A clear dependen...
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Chapter and Conference Paper
Ensuring Observability and Controllability of Complex Technical Systems in Difficult and Irregular Situations When Commands with a Large Distortion Component Are Received
The article looks at some problems of development of an automated information system. This system carries out monitoring and technical control of complex technical systems at nuclear power plants (NPP) and the...
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Article
High-Precision Apparatus for Measurement of the Cut-Off Wavelength of Single-Mode Optical Fiber
Problems that arise in the course of attempting to determine and monitor an optical fiber, the medium of transmission of fiber-optic communication systems, are considered. One of the controllable parameters is...
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Article
Modulation of Calcium-Activated Chloride Currents in Rat Neurons with New 2-Aminotiophene-3-Carboxylic Acid Derivatives
Using the patch-clamp method in the whole cell configuration, it was shown that new conjugates of 2-aminothiophene-3-carboxylic acid with adamantane derivatives exhibit the ability to modulate CaCC activity in...
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Article
New Modulators of NMDA-Receptors Based on Alkyne-Azide Click-Reaction Between 2-Aminothiophene-3-carboxylic Acids Esters and N-Propargyl-Containing Pharmacophores
Copper-catalyzed alkyne-azide 1,3-dipolar cycloaddition of methyl esters of N-azidoacetyl-2-aminothiophene-3-carboxylic acids to N-propargyl-containing pharmacophores, resulting in the corresponding conjugates co...
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Article
New Positive Allosteric Modulator of AMPA Receptors: in vitro and in vivo Studies
A new derivative of 3,7-diazabicyclo[3.3.1]nonane, which showed a high activity as a positive allosteric modulator of AMPA receptors of the CNS, was studied in electrophysiological experiments. At doses of 0.0...
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Article
Methyl N-(carbazolyl)acetyl-2-aminotetrahydrobenzothiophene-3-carboxylates as modulators of NMDA receptors
Methyl N-(carbazolyl)acetyl-2-aminotetrahydrothiophene-3-carboxylates were synthesized by alkylation of carbazoles with the corresponding chloroacetylamides of 2-aminotiophenes. The radioligand binding method sho...
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Article
Methyl esters of 2-aminotetrahydrobenzothiophene-3-carboxylic acids decorated with trifluoromethyl-containing heterocycles
Methyl 2-aminothiophene-3-carboxylates were modified with trifluoromethyl-containing five-membered heterocycles by cyclocondensation of methyl trifluoropyruvate N-thiophen-2-ylimines with 1,3-N,N-binucleophiles (...
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Article
Effect of New Derivatives of 2-Aminothiophene-3-Carboxylic Acid on Calcium-Activated Chloride Currents in Rat Neurons
Using the patch-clamp method in the whole-cell configuration, we showed that the new derivatives of 2-aminothiophene-3-carboxylic acid, which were synthesized by us earlier, can both block (compound 1) and pot...
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Article
Key role of external chloride ions in regulation of fast sodium channels in rat cerebellum Purkinje neurons
A decrease in the external chloride ion concentration to 4 mM caused a decrease in the fast sodium current to 85–100% in rat cerebellum Purkinje neurons in the whole-cell configuration using the patchclamp met...
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Article
Novel conjugates of tacrine with 1,2,4,-thiadiazole as highly effective cholinesterase inhibitors, blockers of NMDA receptors, and antioxidants
Conjugates of tacrine with 1,2,4-thiadiazole derivatives were synthesized for the first time. Their esterase profile and effects on the key NMDA receptor-binding sites as well as antioxidant activity were inve...
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Article
Targeted synthesis and biological activity of polypharmacophoric agents for the treatment of neurodegenerative diseases
Synthetic approaches to the design of new multitarget agents for the treatment of neurodegenerative diseases are surveyed. These approaches are based on the conjugation of the pharmacophoric indole, phenothiaz...
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Article
1,2,4-Thiadiazole derivatives as effective NMDA receptor blockers with anticholinesterase activity and antioxidant properties
New 5-anilino-1,2,4-thiadiazole derivatives with different substituents at position 3 were synthesized and their influence on the key binding sites of NMDA receptors, inhibitory activity against acetylcholines...
