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Pharmakologische Untersuchungen zur antidepressiven Wirkung von Hypericum perforatum L.
Als Ursache von Depressionen werden Serotonin- oder Katecholaminmangelzustände an spezifischen Rezeptoren im zentralen Nervensystem diskutiert [10]. Dieser Theorie entspricht der Wirkmodus der klassischen Anti...
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Elastinolytic activity of alveolar macrophages in smoking-associated pulmonary emphysema
Current concepts of pathomechanisms leading to acquired emphysema suggest that alveolar macrophages (AM) activated by cigarette smoking may cause an elastase/antielastase imbalance localized to the microenviro...
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α1-Proteinase inhibitor and mucus proteinase inhibitor in human lung emphysema
The role of the antiproteases α1-proteinase inhibitor (α1PI) and mucus proteinase inhibitor (MPI) in human lung emphysema was investigated by measuring their amount and functional activity against trypsin, leukoc...
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A macrophage-suppressing 40-kD protein in a case of pulmonary alveolar proteinosis
Pulmonary alveolar proteinosis (PAP) is a rare disease of unknown etiology. Macrophage dysfunctions are claimed to be involved in the pathogenesis. We investigated phagocytosis and oxidative metabolism of alve...
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Article
Human corticotropin-releasing factor (hCRF) is a potent respiratory analeptic
During intravenous corticotropin-releasing factor stimulation tests we observed a deepening of the tidal volume in 35 patients. To investigate this presumed respiratory stimulation we measured respiratory para...
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Article
Hypotensive and antiplatelet actions of motapizone depend on dose and time after ingestion
Single doses of motapizone 1 to 10 mg were given to 12 healthy subjects. Before and up to 8 h after each dose the blood pressure and heart rate were measured, as well as thrombocyte aggregation “ex vivo” with ...
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Inhibition of thrombocyte aggregation by oral motapizone and other drugs
Ten healthy subjects took single oral doses of placebo, 8.8±1.8 mg motapizone, 40±13 mg captopril, 25 mg dihydralazine, 20 mg nifedipine and 4.5±1.1 mg prazosin in random order, and, as the last preparation 50...
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Buchbesprechungen
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Buchbesprechungen
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Detoxification of cyanide in a new-born child
A well-developed male baby was given infusions of 2–5 µg/kg/min of sodium nitroprusside (SNP) in the first few days after birth on account of high arterial blood pressure. After 30 h of treatment, cyanide accu...
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Article
Cytometric investigations in histochemically identified neurons — Changes of fluorescence intensities and nuclear diameters in dopamine neurons of the arcuate nucleus in the cycling rat
The relative formaldehyde-induced fluorescence intensities and the diameter of cell nuclei of fluorescent perikarya of the arcuate nucleus were recorded in serial cross-sectioned hypothalamic arcuate nuclei of...
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Article
Zum Verhalten kardio-pulmonaler Funktionsparameter in Ruhe und unter ergometrischer Belastung bei Myokardinfarktpatienten in der späten Rehabilitationsphase
From 22 patients in the late period of recovery from myocardial infarction, cardio-pulmonary data were recorded at rest and during exercise. The physical work was increased stepwise until patients reached thei...
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Der pulmonale Gaswechsel in der späten Rehabilitationsphase des Myokardinfarktes
In the late period of recovery after myocardial infarction (13–25 months p. infarctum) lung function of 23 patients was examined at rest. Spirometric values and parameters of pulmonary gas exchange showed alte...
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Pulmonaler Gaswechsel in der späten Rehabilitationsphase des Myokardinfarktes
After myocardial infarction in the late period of recovery (13–25 months p. infarctum) pulmonary gas exchange in 23 patients was measured besides as hemodynamic parameters during exercise. The parameters take ...
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Untersuchungen zum pulmonalen Gasaustausch in der akuten Schockphase und nach Übergang in eine Schocklunge
The study of pulmonary gas exchange showed different data of lung function during the acute shock phase and after the development of a shock lung. In 15 patients with different forms of shock and initially unc...
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Article
Die Altersabhängigkeit der arterio-alveolären O2- und CO2-Druckdifferenzen
In a group A (n=65; 20 to 78 years of age) and in a group B (n=35; 22 to 78 years of age) of moderately active men without heart or lung diseases, the arterio-alveolar gas pressure differences (AaDO2 and aADCO2) ...
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Die Verteilungsanalyse von Ventilation, Perfusion und O2-Diffusionskapazität in der Lunge durch Konzentrationswechsel dreier Inspirationsgase
14 adolescents with healthy lungs, 6 elderly people with chronic emphysema bronchitis, and 10 pregnant women with healthy lungs, were examined by the method of distribution analysis of ventilation, ...