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Article
Open AccessAflibercept monotherapy versus aflibercept with targeted retinal laser to peripheral retinal ischemia for diabetic macular oedema (LADAMO)
We tested the hypothesis that targeted retinal laser photocoagulation (TPRP) to peripheral retinal ischaemia reduces the overall burden of aflibercept injections when treating diabetic macular oedema (DMO) ove...
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Article
Open Access5.2: Arterial Stiffness is A Major Independent Determinant of Visit-To-Visit Variability in SBP: A 9.1 Year Follow-Up in Treated Hypertensives
Aortic stiffening, which favours the wave propagation generated by changes in cardiac output, and exaggerates the early return of wave reflection generated by changes in vasomotor tone, can increase the variab...
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Article
Notch signalling suppresses apoptosis in adult human and mouse pancreatic islet cells
The pathogenesis of diabetes and the success of islet transplantation depend on the control of pancreatic beta cell fate. The Notch signalling pathway is essential for normal prenatal pancreatic development, b...
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Article
Glucose oversupply increases Δ9-desaturase expression and its metabolites in rat skeletal muscle
Previous studies have shown that prolonged glucose infusion causes insulin resistance and triglyceride accumulation in rat skeletal muscle. In this study, we investigated a possible relationship between insuli...
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Article
Prolonged glucose infusion into conscious rats inhibits early steps in insulin signalling and induces translocation of GLUT4 and protein kinase C in skeletal muscle
Previous studies on diabetic patients have shown that hyperglycaemia increases glucose uptake in an apparently insulin-independent manner. However, the molecular mechanism has not been clarified.