20 Result(s)

Article

Biodistribution of ¹⁷⁷Lu-DOTA-PSMA in Mice with Prostate Carcinoma 22Rv1

Prostate-specific membrane antigen (PSMA) is overexpressed in prostate cancer and is a well-studied target for therapy of this pathology with PSMA-specific radioligands. The aim of this work was to study the b...

V. K. Tishchenko, V. M. Petriev, O. P. Vlasova… in Pharmaceutical Chemistry Journal (2023)

Article

Biodistribution of Osteotropic ¹⁷⁷Lu-EDTMP – a Potential Radiopharmaceutical for Radionuclide Therapy of Bone Metastases

Phosphonates labeled with beta-emitting radionuclides are widely used in nuclear medicine for palliative therapy of bone metastases. This work was aimed at studying the biodistribution of a new osteotropic ant...

V. K. Tishchenko, V. M. Petriev, A. V. Matveev… in Pharmaceutical Chemistry Journal (2022)

Article

Compartmental Modeling of the Kinetics of ¹⁸⁸Re-Labeled Pentaphosphonic Acid in Rats with Bone Callus

Phosphonic acids labeled with rhenium-188 (¹⁸⁸Re) are promising bone-seeking radiopharmaceuticals (RPs) for bone metastases therapy. The present work was aimed to develop a compartmental mathematical model of ¹⁸⁸

A. V. Matveev, V. M. Petriev, V. K. Tishchenko in Pharmaceutical Chemistry Journal (2022)

Article

Pharmacokinetics in Intact Rats of N,N,N′,N′-Ethylenediaminetetrakis-(Methylenephosphonic Acid) Labeled with Gallium-68

Pharmacokinetic studies of the new bone-seeking radiopharmaceutical (RP) ⁶⁸Ga-labeled N,N,N′,N′-ethylenediaminetetrakis(methylenephosphonic acid) (EDTMP) for PET diagnosis of bone metastases showed that ⁶⁸Ga-EDTM...

V. M. Petriev, V. K. Tishchenko, O. A. Smoryzanova… in Pharmaceutical Chemistry Journal (2017)

Article

¹⁸F-FDG and Other Labeled Glucose Derivatives for Use in Radionuclide Diagnosis of Oncological Diseases (Review)

This review addresses progress in the radionuclide diagnosis of oncological diseases using radiopharmaceutical preparations (RPP) based on labeled glucose derivatives. Most attention is paid to 2-[¹⁸F]fluoro-2-de...

V. M. Petriev, V. K. Tishchenko, R. N. Krasikova in Pharmaceutical Chemistry Journal (2016)

Article

Radiopharmaceuticals Based on Polyaminophosphonic Acids Labeled with α−, β−, and γ-Emitting Radionuclides (Review)

This review presents results on the pharmacokinetic characteristics of osteotropic radiopharmaceuticals (RP) based on polyaminophosphonic acids labeled with various radionuclides. The greatest number of studie...

V. K. Tishchenko, V. M. Petriev, V. G. Skvortsov in Pharmaceutical Chemistry Journal (2015)

Article

The Pharmacokinetics of Technetium-99m-Labeled N,N,N′,N′-Ethylenediaminetetra-Kis-(Methylenephosphonic Acid) in Intact Rats

Pharmacokinetic studies of technetium-99m-labeled N,N,N′,N′-ethylenediaminetetra-kis-(methylenephosphonic acid) (^99mTc-EDTMP) showed that this radiopharmaceutical (RP) has high in vivo stability. Studies of the b...

V. M. Petriev, V. K. Tishchenko, K. V. Koptyaeva… in Pharmaceutical Chemistry Journal (2015)

Article

Pharmacokinetic Study of the New Diagnostic Radiopharmaceutical ^99mTc-Pentaphosphonic Acid in Rats with an Experimental Bone-Fracture Model

The pharmacokinetic properties of a bone-seeking radiopharmaceutical based on pentaphosphonic acid labeled with technetium-99m (^99mTc-PPA) were investigated. The experiments were performed in healthy rats and in ...

V. M. Petriev, V. K. Tishchenko, O. V. Siruk… in Pharmaceutical Chemistry Journal (2014)

Article

Pharmacokinetic Characteristics of the Radiopharmaceutical “¹⁸⁸Re-Albumin Microspheres” After Intravenous Administration to Laboratory Animals

Studies of the pharmacokinetics of ¹⁸⁸Re-human serum albumin microspheres (MSA) of diameter 10 – 20 μm in intact mice showed that the maximum accumulation of activity (about 70%) 5 min at after intravenous admini...

V. M. Petriev, O. V. Siruk, A. A. Bryukhanova… in Pharmaceutical Chemistry Journal (2014)

Article

Studies of the Pharmacokinetics of Actinium-255-Labeled Bisphosphonate in Intact Mice

The pharmacokinetics of ²²⁵Ac-labeled hydroxyethylenediphosphoric acid monopotassium salt (²²⁵Ac-KHEDP) and ²²⁵AcCl₃ were studied in intact mice after intravenous administration. The results obtained here showed ...

V. M. Petriev, V. K. Podgorodnichenko… in Pharmaceutical Chemistry Journal (2013)

Article

Pharmacokinetics of ¹⁸⁸Re-labeled pentaphosphonic acid in rats with experimental bone callosity

The influence of modeled femur callosity on the biodistribution of ¹⁸⁸Re-labeled pentaphosphonic acid (¹⁸⁸Re-PPA) in rats was studied. The radiopharmaceutical was injected into a tail vein 14 d after fracture. It...

V. K. Shiryaeva, V. M. Petriev, O. A. Smoryzanova… in Pharmaceutical Chemistry Journal (2013)

Article

Evaluation of the influence of preparation conditions on pharmacokinetics of bone-seeking radiopharmaceutical ¹⁸⁸Re-labeled hydroxyethylidenediphosphonic acid monopotassium salt in rats

The in vivo biodistributions of the monopotassium salt of hydroxyethylidenediphosphonate labeled with ¹⁸⁸Re (¹⁸⁸Re-KHEDP) were studied in rats for drug batches prepared with and without Re carrier. Also, the phar...

V. K. Shiryaeva, V. M. Petriev, A. A. Bryukhanova… in Pharmaceutical Chemistry Journal (2012)

Article

Pharmacokinetics of a new radiopharmaceutical based on alubmin microspheres and palladium-103 and modified by heat and radiation

The pharmacokinetics of albumin microspheres (AMS) labeled with ¹⁰³Pd (¹⁰³Pd-AMS) were studied in healthy mice after intramuscular injections. It was established that increasing the denaturation temperature of al...

V. M. Petriev, V. K. Shiryaev, V. G. Skvortsov… in Pharmaceutical Chemistry Journal (2011)

Article

Comparative analysis of pharmacokinetic characteristics of radiopharmaceuticals based on the monopotassium salt of 1-hydroxyethylidenediphosphonic acid labeled by ^99mT9c and ¹⁸⁸Re

Investigation of pharmacokinetic characteristics of the ^99mTc- and ¹⁸⁸Re-labeled monopotassium salt of 1-hydroxyethylidenediphosphonic acid (KHEDP) in rats showed that the level of accumulated activity at 5 min a...

V. K. Shiryaeva, V. M. Petriev, A. A. Bryukhanova… in Pharmaceutical Chemistry Journal (2011)

Article

Osteotropic radiopharmaceuticals based on phosphonic acids for the treatment of bone metastases in humans (review)

This review describes the advantages and disadvantages of radionuclides used in the development of radiopharmaceuticals for radionuclide therapy. Comparison of the characteristics of various radionuclides lead...

V. M. Petriev, E. L. Afanas’eva, V. G. Skvortsov in Pharmaceutical Chemistry Journal (2008)

Article

Distribution of sodium perrenate in intact mice

The distribution of sodium perrenate (Na¹⁸⁸ReO₄) in the organism of intact mice has been studied. It is shown that the behavior of Na¹⁸⁸ReO₄ in the organism depends on the method of administration. In particular,...

V. M. Petriev, O. A. Smoryzanova, V. G. Skvortsov in Pharmaceutical Chemistry Journal (2007)

Article

Immunoglobulin: DNA cofactor interaction

The reasons for the appearance of DNA-binding activity of immunoglobulins (Ig) after chromatography on anion-exchange Sephadexes were studied. Elution of Ig from these Sephadexes with 0.5 M NaCl was found, usi...

M. K. Malinka, V. M. Petriev, V. K. Podgorodnichenko in Pharmaceutical Chemistry Journal (2007)

Article

Production of [⁵⁷Co]bleomycetin and study of its kinetics in the bodies of intact animals and tumor-bearing animals

V. M. Petriev, Dzh G. Khachirov, R. M. Prusova in Pharmaceutical Chemistry Journal (1982)

Article

Pharmacokinetics of [^99mTc]acetylmethionine in the organism of tumor-bearing animals

Dzh G. Khachirov, V. M. Petriev, Yu. I. Savin… in Pharmaceutical Chemistry Journal (1979)

Article

Preparation of N-C₄-[¹²⁵I]pyrazolylmethyltetracycline and study of its behavior in the organism of intact and tumor-bearing animals

Dzh G. Khachirov, V. M. Petriev, P. P. Filatov… in Pharmaceutical Chemistry Journal (1979)