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  1. No Access

    Article

    Feeding behavior during long-term hexarelin administration in young and old rats

    Ghrelin, a 28-amino-acid peptide isolated from the stomach, is the natural ligand of the GH-secretagogues receptor-1a (GHS-R1a) and, so far, the only discovered circulating appetite-stimulating hormone. Simila...

    E. Bresciani PhD, N. Pitsikas, L. Tamiazzo… in Journal of Endocrinological Investigation (2008)

  2. No Access

    Article

    Central dysregulations in the control of energy homeostasis and endocrine alterations in anorexia and bulimia nervosa

    In the last decades we have come to understand that the hypothalamus is a key region in controlling energy homeostasis. A number of control models have been proposed to explain the regulation of feeding behavi...

    A. Torsello MD, F. Brambilla, L. Tamiazzo… in Journal of Endocrinological Investigation (2007)

  3. No Access

    Article

    Intracerebroventricular acute and chronic administration of obestatin minimally affect food intake but not weight gain in the rat

    We studied the effect of the acute central administration of obestatin on food intake and body weight in short-term starved male rats, and those of 28-day continuous intracerebroventricular (icv) infusion of o...

    V. Sibilia, E. Bresciani, N. Lattuada… in Journal of Endocrinological Investigation (2006)

  4. No Access

    Article

    Obestatin inhibits feeding but does not modulate GH and corticosterone secretion in the rat

    Obestatin is a recently discovered 23 amino acids peptide derived from the ghrelin gene. As opposed to ghrelin, obestatin was shown to inhibit food intake in mice. The aims of this research were to study the e...

    E. Bresciani PhD, D. Rapetti, F. Donà… in Journal of Endocrinological Investigation (2006)

  5. No Access

    Article

    Ghrelin in gastroenteric pathophysiology

    Ghrelin, an acylated peptide produced predominantly by the stomach, has been discovered to be a natural ligand of the growth hormone secretagogue receptor 1 a (GHS-R1 a). It is localized in distinct cells of t...

    V. Locatelli, E. Bresciani, I. Bulgarelli… in Journal of Endocrinological Investigation (2005)

  6. No Access

    Article

    IGF-I stimulates proliferation of spontaneously immortalized human keratinocytes (HACAT) by autocrine/paracrine mechanisms

    HaCaT keratinocytes are derived from adult human skin and although spontaneously immortalized, remain highly related to their normal counterparts. We observed that HaCaT cells can proliferate in serum-free med...

    G. Pozzi, M. Guidi, F. Laudicina, M. Marazzi… in Journal of Endocrinological Investigation (2004)

  7. No Access

    Article

    Moexipril and quinapril inhibition of tissue angiotensin-converting enzyme activity in the rat: Evidence for direct effects in heart, lung and kidney and stimulation of prostacyclin generation

    The activation of angiotensin converting enzyme (ACE) may contribute to the development of vascular and myocardial structural changes. The level of ACE is stable in human plasma, and only limited data are avai...

    Dr. Antonio Torsello, V. Locatelli… in Journal of Endocrinological Investigation (2003)

  8. No Access

    Chapter and Conference Paper

    Endocrine and Extraendocrine Activity of Ghrelin and the GHS: Basic Research

    Until few years ago it was generally accepted that the secretion of growth hormone (GH) was mainly regulated by stimulatory and inhibitory influences of two hypothalamic hypophysiotropic hormones, the growth h...

    E. Bresciani, A. Torsello, R. Avallone… in Peptides and Non Peptides of Oncologic and… (2003)

  9. No Access

    Article

    EP1572: A novel peptido-mimetic GH secretagogue with potent and selective GH-releasing activity in man

    EP1572 (JMV1843 [Aib-DTrp-DgTrp-CHO]) is a new peptido-mimetic GH secretagogue (GHS) showing binding potency to the GHS-receptor in animal and human tissues similar to that of ghrelin and peptidyl GHS. EP1572 ...

    F. Broglio, F. Boutignon, A. Benso, C. Gottero… in Journal of Endocrinological Investigation (2002)

  10. No Access

    Chapter

    Impervious peptides as growth hormone secretagogues

    R. Deghenghi, F. Boutignon, G. Muccioli, E. Ghigo… in Peptide Science — Present and Future (2002)

  11. No Access

    Article

    New growth hormone secretagogues

    Starting from EP 51389, a potent growth hormone secretagogue(GHS), a new series of GHS has been designed, synthesized andtested. This series was built on a gem-diamino moiety and astructure activity relationsh...

    V. Guerlavais, D. Boeglin, J.A. Fehrentz, R. Deghenghi… in Letters in Peptide Science (2001)

  12. No Access

    Article

    Binding of 125I-labeled ghrelin to membranes from human hypothalamus and pituitary gland

    Ghrelin has been proposed as a natural ligand of the GH secretagogue receptor(s) (GHS-R), which was an orphan receptor activated by synthetic peptidyl (hexarelin) and non-peptidyl (MK-0677) GHS to strongly rel...

    Dr G. Muccioli, M. Papotti, V. Locatelli… in Journal of Endocrinological Investigation (2001)

  13. No Access

    Article

    EP 60761- and EP 50885-induced penile erection: structure–activity studies and comparison with apomorphine, oxytocin and N-methyl-D-aspartic acid

    The effect of 10 peptides structurally related to the growth hormone (GH) releasing peptide hexarelin, injected into the paraventricular nucleus of the hypothalamus (PVN), on penile erection was studied in mal...

    MR Melis, MS Spano, S Succu, V Locatelli… in International Journal of Impotence Research (2000)

  14. No Access

    Article

    Effects of GH and IGF-I administration on GHRH and somatostatin mRNA levels: II. A study in the infant rat

    It is generally accepted that growth hormone influences its own secretion by modulating the activity of GHRH and SRIF neurons. To investigate if GH feedback mechanisms are already operating in the early postna...

    R. Grilli, M. C. Ghigo, A. Torsello, M. Guidi… in Journal of Endocrinological Investigation (1997)

  15. No Access

    Article

    Effects of GH and IGF-I administration on GHRH and somatostatin mRNA levels: I a study on ad libitum fed and starved adult male rats

    The individual role played by GH and IGF-I in the regulation of hypothalamic GHRH and SRIF gene expression is still object of debate. We have investigated the effect of exogenously administered recombinant hGH...

    M. C. Ghigo, A. Torsello M.D., R. Grilli… in Journal of Endocrinological Investigation (1997)

  16. No Access

    Article

    A Comparison of Nimesulide and Placebo in the Treatment of Minor Traumatic Soft Tissue Lesions in Children

    A total of 40 children with minor traumatic injuries of soft tissues were randomly assigned to oral treatment with nimesulide (50mg twice daily) or placebo for 5 days in a double-blind investigation. Results d...

    Prof. M. Giovannini, G. V. Zuccotti, I. Scaricabarozzi, V. Locatelli, E. Riva in Drugs (1993)

  17. No Access

    Chapter and Conference Paper

    Growth Hormone: Neural Mechanisms of Control at Neonatal and Aged Periods

    It is now an indisputable concept that the secretion of growth hormone (GH) is regulated by the central nervous system (CNS). Two specific hypothalamic neuropeptides, GH-releasing hormone (GHRF) and somatostat...

    V. Locatelli, S. G. Cella, D. Cocchi… in Growth Hormone and Somatomedins during Lif… (1993)

  18. No Access

    Chapter

    Opioid Peptides in the Regulation of Anterior Pituitary Hormones

    Extensive research over the last 20 years has shown that in addition to classic hypothalamic regulatory hormones (RHs) (Table 1), a variety of other peptides exist in the central nervous system (CNS) of mammals.

    S. G. Cella, V. Locatelli, E. E. Müller in Opioids II (1993)

  19. No Access

    Article

    Involvement of Brain Catecholamines and Acetylcholine in Growth Hormone Deficiency States

    A cohort of brain neurotransmitters, especially catecholamines and acetylcholine, play a crucial role in the control of neurosecretory growth hormone-releasing hormone (GH-RH)- and somatostatin (SS)-producing ...

    Dr Eugenia E. Müller, V. Locatelli, E. Ghigo, S. G. Cella, S. Loche, C. Pintor… in Drugs (1991)

  20. No Access

    Chapter and Conference Paper

    Growth hormone deficiency states: approach by CNS-acting compounds

    Over the past few years, a number of new findings have led to a better understanding of the pathophysiology of growth hormone (GH) secretion. The isolation of GH-releasing hormone (GHRH) (Guillemin et al. 1982...

    C. Pintor, S. Loche, R. Puggioni… in Advances in Growth Hormone and Growth Fact… (1989)

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