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    Chapter

    Chromosome differentiation using nucleases: an overview

    The era of the longitudinal differentiation of metaphase chromosomes (chromosome banding) dawned in 1968 when Caspersson and coworkers described the use of quinacrine mustard as a fluorescent compound which he...

    J. Gosálvez, C. López-Fernández, V. Goyanes, R. Mezzanotte in Chromosomes Today (1997)

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    Article

    Electron microscopy and biochemical analysis of mouse metaphase chromosomes after digestion with restriction endonucleases

    Electron microscopy (EM) of whole mounted mouse chromosomes, light microscopy (LM), and agarose gel electrophoresis of DNA were used to investigate the cytological effect on chromosomes of digestion with the r...

    J. Gosálvez, A. T. Sumner, C. López-Fernández, R. Rossino, V. Goyanes in Chromosoma (1990)