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Article
Synthesis and intramolecular transformations of 8-substituted 11-nitro-2-phenyl-5,6-dihydro-2H-2,6-methanobenzo[g][1,3,5]oxadiazocin-4(3H)-one diastereomers
The Biginelli reaction between 5-R-salicylic aldehyde (R = H, Me, and Br), α-nitroacetophenone, and urea affords 8-R-11-nitro-2-phenyl-5,6-dihydro-2H-2,6-methanobenzo-[g][1,3,5]oxadiazocin-4(3Н)-ones as mixtures ...
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Article
Synthesis and intramolecular conversion of substituted 2-methyl-11-nitro-5,6-dihydro-2H-2,6-methanobenzo[g][1,3,5] oxadiazocin-4(3H)-ones in different solvents
A Biginelli reaction of 5-R-salicylic aldehydes (R = H, Me, Br) with nitroacetone and urea in each case leads to a predominant formation of 2R*,6S*,11S* diastereomers of 8-R-2-methyl-11-nitro-5,6-dihydro-2H-2,6-m...
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Article
Features of the behavior of 5-substituted N(3)-acyl-4,6-diaryl-3,4-dihydropyrimidin-2(1H)-ones under electron ionization
Mass spectra of 5-substituted N(3)-acyl-4,6-diaryl-3,4-dihydropyrimidin-2(1H)-ones are studied. The features of the dissociative ionization of their molecular ions, which occurs with ketene elimination from the a...
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Article
Selective acylation of 5-nitro- and 5-ethoxycarbonyl-4,6-diaryl-3,4-dihydropyrimidin-2(1H)-ones
The acetylation and chloroacetylation of 5-nitro- and 5-ethoxycarbonyl-substituted 4,6-diaryl-3,4-dihydropyrimidin-2(1H)-ones proceeds regioselectively at the N3 atom of the heterocycle whereas the acetylation of...
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Article
Synthesis of substituted 3,4-dihydropyrimidin-2(1H)-ones and pyrimidin-2(1H)-ones by the Biginelli reaction with 3,5-Di-tert-butyl-4-hydroxybenzaldehyde
Three-component acid-catalyzed cyclocondensation of 3,5-di-tret-butyl-4-hydroxybenzaldehyde with urea and ethyl acetoacetate or α-nitroacetophenone (Biginelli reaction) under homogeneous conditions gave the corre...
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Article
Three-component condensation of α-nitroacetophenone, aromatic aldehydes, and methylurea
The three-component condensation of aromatic aldehydes, methylurea, and α-nitroacetophenone affords both N(1)-and N(3)-methyl-substituted 4,6-diaryl-5-nitro-3,4-dihydropyrimidin-2(1H)-ones depending on the struct...
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Article
Synthesis of 5-nitro-3,4-dihydropyrimidin-2(1H)-ones catalyzed by metal salts. Retro-Henry reaction with formation of N,N′-disubstituted ureas
Three-component condensation of α-nitroacetophenone with aromatic aldehydes and urea in the presence of iron(III), cobalt(II), nickel(II), and copper(II) salts as catalyst led to the formation of 4,6-diaryl-5-...
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Article
Bromination-Dehydrobromination of 4-Aryl-5-nitro-6-phenyl-3,4-dihydropyrimidin-2(1H)-ones
Depending on the conditions, bromination of 4-aryl-5-nitro-6-phenyl-3,4-dihydropyrimidine-2(1H)-ones and subsequent dehydrobromination gives either 4-aryl-5-nitro-6-phenylpyrimidin-2(1H)-ones or their mixtures wi...
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Article
Crystal Structures of 5-Nitro- and 5-Ethoxycarbonyl-Substituted 6-Phenyl-4-(3-fluorophenyl)-3,4-dihydro-(1H)-pyrimidin-2-ones
The crystal structures of 5-nitro- and 5-ethoxycarbonyl-substituted 6-phenyl-4-(3-fluorophenyl)-3,4-dihydro-(1H)-pyrimidin-2-ones were determined by X-ray diffraction analysis. Conformational peculiarities of the...
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Article
Two Directions of the Reaction of 4-Bromobenzaldehyde with Substituted Acetophenones and Urea. Synthesis of Aryl-substituted Pyrimidin-2-one and Hexahydropyrimido[4,5-d]pyrimidin-2,7-dione
Condensation of 4-bromobenzaldehyde, urea, and 4-alkyl-substituted acetophenones gave substituted hexahydro-1H,8H-pyrimido[4,5-d]pyrimidin-2,7-diones or 1H-pyrimidin-2-ones, depending on the substituent on the ac...
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Article
Formation of substituted 6-hydroxy-5-oxo-5,6-dihydrobenzo[c][2,7]naphthyridine upon photochemical transformation of nifedipine
Long-term exposure of nifedipine to daylight in ethanol gives 2,2"-bis[3,5-bis(methoxycarbonyl)-2,6-dimethylpyridin-4-yl]azoxybenzene and 6-hydroxy-1-methoxycarbonyl-2,4-dimethyl-5-oxo-5,6-dihydrobenzo[c][2,7]nap...
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Article
Crystal Structure of the Azoxy Compound Formed by Photochemical Transformation of Niphedipine
The crystal structure of 2,2'-bis[2,6-dimethyl-3,5-di(methoxycarbonyl)pyridinyl-4]azoxybenzene has been determined; the compound is formed as the major product of photodegradation of niphedipine subjected to p...
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Article
Synthesis and Antiarrhythmic Effect of 4-Aryl-5-nitro-6-phenyl-3,4-dihydro-(1H)-pyrimidin-2-ones
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Article
Crystal Structure of 5-Nitro-4-(2-nitrophenyl)-6-phenyl-3,4-dihydro-(1H)-pyrimidin-2-one
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Article
Synthesis of 2-Amino- and 2-Hydrazino-substituted 5-Nitro-4,6-diphenylpyrimidines
Nitrogen-containing derivatives of 5-nitro-4,6-diphenylpyrimidine have been synthesized by the reaction of 2-chloro-5-nitro-4,6-diphenylpyrimidine with amines or of 2-hydrazino-5-nitro-4,6-diphenylpyrimidine w...
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Article
Diaryldihydropyrimidine-2-ones, a Prospective Group of Antiarrhythmic Agents
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Article
Crystal Structure of 6-Chloro-4-nitro-2-phenylpyrimidine
The crystal structures of 6-chloro-4-nitro-2-phenylpyrimidine and 6-chloro-2-phenylpyrimidine have been determined using X-ray diffraction. The effect of the nitro group and the endocyclic nitrogen atoms on th...
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Article
Crystal structure of 4,6-dimethyl-2-nitro-and 2-nitro-5-phenylpyrimidines
The crystal structures of two substituted 2-nitropyrimidines are solved by X-ray diffraction analysis. The influence of the nitro group and the endocyclic nitrogen atoms on the geometric parameters of the 2-ni...
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Article
Crystal structure of 2-nitropyridine
The crystal structure of 2-nitropyridine has been determined by x-ray diffraction analysis. The influence of the nitro group on the geometric parameters of the molecule was evaluated, as well as its influence ...
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Article
Polycyclic rod-shaped azo dyes based on aminophenylpyrimidines
We have synthesized rod-shaped tricyclic monoazo and bisazo dyes based on amino derivatives of arylpyrimidines and N,N-dialkylanilines orp-nitroso-N,N-dialkylanilines. We have shown that the process of azo coupli...
