-
Article
Development and Full-Scale Testing of Prototypes of Tsdss-M and MDM Digital Seafloor Seismic Stations Intended for Security Systems
The paper addresses experiments to assess whether seismic systems can be used for autonomous border surveillance on land and sea. Seismic systems as an integral part of border surveillance systems, especially ...
-
Article
SM-3MU Small-Size Uniform Seismic Module for High-Resolution Seismometers
The paper describes the development of a new small-size seismic module (SM-3MU) whose characteristics are close to those of SM-3 seismometers. The module operates as a velocimeter with an electronic amplifier,...
-
Article
A Seismic Bottom Station Based on a Molecular Electron Seismometer for Shelf Areas and Transitional Zones
This paper is concerned with the design of a portable seismic bottom station (PSBS) based on a molecular electron seismometer for research in seismology and volcanology (Sobisevich et al., 2008) and for dealin...
-
Article
Validation of a Method for Assay of Trifluoroacetates in the Pharmaceutical Substance Glatiramer Acetate by 19F NMR Spectroscopy
A procedure for validation of an assay method for fluorine in residual trifluoroacetates in the pharmaceutical substance glatiramer acetate by 19F NMR spectroscopy is described. The method provides for assay of t...
-
Article
Comparative Analysis of the Heavy Metal, Aluminum, and Arsenic Contents in Brown Algae of Various Origins
The results of measurements of trace element contents in brown algae of the families Laminariales and Fucales of different origins are presented, along with supplementary data from the literature. Aluminum, ca...
-
Article
A Family of Seismometers with Capacitive Transducers
A family of seismometers has been developed with capacitive transducers that convert the relative displacement between the inertial mass and the base of the instrument into an electric signal. These high-sensi...
-
Article
Validation of an NMR-Spectroscopic Method for Authenticity Confirmation of Buserelin Acetate Pharmaceutical Substance
The specificity of different variants of an NMR spectroscopic method for authenticity confirmation of buserelin acetate drug substance was estimated by comparing PMR and 13C NMR spectra of buserelin acetate and [...
-
Article
Development of an Industrial Reference Sample for the Specific Activity of Erythropoietin
On the basis of WHO recommendations and the principles developed for the standardization of erythropoietins we selected one epoetin alfa pharmaceutical substances included in the State Register of Medicines as...
-
Article
A New-Generation Borehole Electrodynamic Seismometer for Seismological Research
This paper reports the development of a new-generation short-period borehole electrodynamic seismometer designed for research, with special emphasis on seismology and volcanology (Sobisevich et al., 2008) and ...
-
Article
Development of a Procedure for Identification of Biperiden Hydrochloride with Specificity for Triperiden Hydrochloride
Biperiden hydrochloride, (1RS)-1-[(1RS, 2SR, 4RS)-bicyclo[2.2.1]hept-5-en-2-yl]-1-phenyl-3-(piperidin-1-yl)prop an-1-ol hydrochloride, is one of the most efficacious cholinolytics. It is used to treat Parkinson’s...
-
Article
Validation of a Method of Measuring Mean Molecular Weight of Dextrans by Diffusion-Ordered Spectroscopy
Amethod for measuring the mean molecular weight of dextrans by diffusion-ordered NMR spectroscopy was developed and validated. This method allows measurements of dextran self-diffusion coefficients to determin...
-
Article
Development of a Method for Determining the Amino Acid Composition of the Pharmaceutical Substance “Glatiramer Acetate” by NMR Spectroscopy
The acid hydrolysis procedure for glatiramer acetate was modified and the characteristic signals in the 1H and 13C spectra were identified, allowing its amino acid composition to be determined. The relative molar...
-
Article
Pharmacopeia Standard Samples and Their Practical Application in the National Drug Standardization System
Standard samples constitute one of the key elements in the medicines standardization system. In pharmacopeia analysis in the Russian Federation and many foreign countries, the use of standard samples is regula...
-
Article
Validation of a Method for Measuring the Molar Substitution of Hydroxyethylstarches by 1H NMR Spectroscopy
Amethod for determining molar substitution of hydroxyethylstarches by 1H NMR spectroscopy was validated in terms of specificity, linearity, correctness, precision, and range of application. The method can be used...
-
Article
Comparative analysis of the characteristics of domestic and foreign broadband seismometers with capacitive transducers
A family of seismometers has been developed with capacitive transducers that convert the relative displacement between the inertial mass and the base of the device into an electric signal. The seismometers hav...
-
Article
Analysis of Factors Influencing the Interchangeability of Antiepileptic Drugs
The presence of several generics on the pharmaceutical market makes it possible to create a competitive environment and helps to reduce the costs of drug therapy. RF Government Decree No. 1154 of October 28, 2...
-
Article
Effects of Molar Substitution on the Mobility of Hydroxyethylstarch Macromolecules in Solution
The effects of molar substitution of hydroxyethylstarch on the macromolecule mobility in solution were studied by diffusion-ordered NMR spectroscopy (1H-DOSY) to measure mean self-diffusion coefficients of hydrox...
-
Article
Synthesis and Antibacterial Activity of Bis-[1-(Adamantan-1-Yl)Ethyl]Amine Hydrochloride
An impurity in rimantadine hydrochloride drug substance that was previously undescribed in regulatory documents and the literature was identified. Its structure was elucidated and confirmed by a convergent syn...
-
Article
Modern Approaches to the Development of Reference Standards for Quality Assessment of Drug Substances
Reference standards, including pharmacopoeial reference standards, are widely used for quality assessment of drug substances. Leading global pharmacopoeias contain monographs regulating the requirements for th...
-
Article
Modification of PMR Spectroscopy Technique for Determination of the Molar Substitution in Hydroxyethyl Starch
The PMR spectroscopy technique for determining the molar substitution (MS) in hydroxyethyl starch (HES) was modified. It was shown that allowance for integrated intensities of resonances for anomeric H(1) prot...
