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  1. Article

    Open Access

    Triple blockade of EGFR, MEK and PD-L1 has antitumor activity in colorectal cancer models with constitutive activation of MAPK signaling and PD-L1 overexpression

    Molecular mechanisms driving acquired resistance to anti-EGFR therapies in metastatic colorectal cancer (mCRC) are complex but generally involve the activation of the downstream RAS-RAF-MEK-MAPK pathway. Never...

    S. Napolitano, N. Matrone, A. L. Muddassir… in Journal of Experimental & Clinical Cancer … (2019)

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  2. No Access

    Article

    XB130, a tissue-specific adaptor protein that couples the RET/PTC oncogenic kinase to PI 3-kinase pathway

    XB130 is a recently cloned 130 kDa-adaptor protein and Src kinase substrate, structurally similar to actin-filament-associated protein. Here we show that XB130 is predominantly expressed in the thyroid. Given ...

    M Lodyga, V De Falco, X-h Bai, A Kapus, R M Melillo, M Santoro, M Liu in Oncogene (2009)

  3. No Access

    Article

    Biochemical and molecular characterization of the novel BRAFV599Ins mutation detected in a classic papillary thyroid carcinoma

    Activating mutations of the BRAF gene are the most common genetic alterations in papillary thyroid carcinomas (PTCs) and the T1799A transversion, resulting in BRAFV600E, appeared virtually unique in this cancer t...

    S Moretti, A Macchiarulo, V De Falco, N Avenia, F Barbi, C Carta, A Cavaliere… in Oncogene (2006)

  4. No Access

    Article

    Paradoxical effect of dexamethasone administration to rabbits with antigen-induced arthritis

    Systemic dexamethasone phosphate administration to rabbits 2 h before induction of arthritis by antigen promoted a decrease in cellular influx, vascular permeability and eicosanoid concentrations in the synovi...

    A. J. De Brum-Fernandes, V. De Falco, F. A. Castro da Rocha… in InflammoPharmacology (1992)