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Article
Open AccessCorrection: EGFL7 loss correlates with increased VEGF-D expression, upregulating hippocampal adult neurogenesis and improving spatial learning and memory
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Article
Open AccessEpigenetic inactivation of the 5-methylcytosine RNA methyltransferase NSUN7 is associated with clinical outcome and therapeutic vulnerability in liver cancer
RNA modifications are important regulators of transcript activity and an increasingly emerging body of data suggests that the epitranscriptome and its associated enzymes are altered in human tumors.
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Article
Open AccessEGFL7 loss correlates with increased VEGF-D expression, upregulating hippocampal adult neurogenesis and improving spatial learning and memory
Neural stem cells reside in the subgranular zone, a specialized neurogenic niche of the hippocampus. Throughout adulthood, these cells give rise to neurons in the dentate gyrus, playing an important role in le...
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Protocol
Target-Specific Profiling of RNA m5C Methylation Level Using Amplicon Sequencing
Map** the position and quantifying the level of 5-methylcytosine (m5C) as a modification in different types of cellular RNA is an important objective in the field of epitranscriptomics. Bisulfite conversion has...
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Article
Open AccessFunctional microRNA targetome undergoes degeneration-induced shift in the retina
MicroRNA (miRNA) play a significant role in the pathogenesis of complex neurodegenerative diseases including age-related macular degeneration (AMD), acting as post-transcriptional gene suppressors through thei...
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Article
Avoiding Internal Injector Deposits by Using Biodiesel
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Article
Vermeidung interner Injektorbeläge durch den Einsatz von Biodiesel
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Article
Open AccessInhibition of microRNA-155 Protects Retinal Function Through Attenuation of Inflammation in Retinal Degeneration
Although extensively investigated in inflammatory conditions, the role of pro-inflammatory microRNAs (miRNAs), miR-155 and miR-146a, has not been well-studied in retinal degenerative diseases. We therefore aim...
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Article
Test zur Belagsbildungsneigung von Dieselkraftstoffen in Injektoren
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Article
Deposit Forming Tendency of Diesel Fuels in Injectors
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Article
Open AccessMultiple links between 5-methylcytosine content of mRNA and translation
5-Methylcytosine (m5C) is a prevalent base modification in tRNA and rRNA but it also occurs more broadly in the transcriptome, including in mRNA, where it serves incompletely understood molecular functions. In pu...
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Article
Effects of New Gasoline on the Aging of Lubricants
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Article
Einfluss neuer Ottokraftstoffe auf die Alterung von Schmierstoffen
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Article
Open AccessEpigenetic loss of RNA-methyltransferase NSUN5 in glioma targets ribosomes to drive a stress adaptive translational program
Tumors have aberrant proteomes that often do not match their corresponding transcriptome profiles. One possible cause of this discrepancy is the existence of aberrant RNA modification landscapes in the so-call...
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Article
Open AccessMultiplicative modelling of four-phase microbial growth
Microbial growth curves, recording the four-phases (lag, growth, stationary, decay) of the dynamics of the surviving microbes, are regularly used to support decision-making in a wide variety of health related ...
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Chapter and Conference Paper
Alteration of fuel properties at extreme conditions – Formation of deposits in common-rail injectors
Engine and FIE manufacturers are facing an increased number of complaints on abnormal engine functioning related to internal diesel injector deposits (IDID). Possible consequences are increased emissions, roug...
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Article
Open AccessDNA demethylases target promoter transposable elements to positively regulate stress responsive genes in Arabidopsis
DNA demethylases regulate DNA methylation levels in eukaryotes. Arabidopsis encodes four DNA demethylases, DEMETER (DME), REPRESSOR OF SILENCING 1 (ROS1), DEMETER-LIKE 2 (DML2), and DML3. While DME is involved in...
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Protocol
Simple Quantification of In Planta Fungal Biomass
An accurate assessment of the disease resistance status of plants to fungal pathogens is an essential requirement for the development of resistant crop plants. Many disease resistance phenotypes are partial ra...
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Article
Open AccessAnalysis of hairpin RNA transgene-induced gene silencing in Fusarium oxysporum
Hairpin RNA (hpRNA) transgenes can be effective at inducing RNA silencing and have been exploited as a powerful tool for gene function analysis in many organisms. However, in fungi, expression of hairpin RNA t...
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Article
Open AccessA fast and efficient method for preparation of high-quality RNA from fungal mycelia
Fungal RNA samples are usually isolated from fungal mycelia grown in liquid culture, which relies on prolific growth of the fungus in liquid media. The fungal biomass is then collected by vacuum filtration, wh...
