54 Result(s)

Article

Dose-reduced conditioning for allogeneic blood stem cell transplantation: durable engraftment without antithymocyte globulin

Between February 1998 and October 1999, 24 patients with advanced leukemia, lymphoma or solid tumors received G-CSF mobilized peripheral blood stem cells (PBSC) from HLA-matched sibling donors after dose-reduc...

M Bornhäuser, C Thiede, U Schuler, U Platzbecker… in Bone Marrow Transplantation (2000)

Article

Acute heart failure after allogeneic blood stem cell transplantation due to massive myocardial infiltration by cytotoxic T cells of donor origin

A 17-year-old male with AML FAB M4 relapsed 4 months after myeloablative conditioning and peripheral blood stem cell transplantation (PBSCT) from an HLA-identical unrelated donor. A second PBSC harvest was inf...

U Platzbecker, K Klingel, C Thiede, J Freiberg-Richter… in Bone Marrow Transplantation (2001)

Article

Early allogeneic blood stem cell transplantation after modified conditioning therapy during marrow aplasia: stable remission in high-risk acute myeloid leukemia

Two patients with high-risk acute myeloid leukemia (AML) whose bone marrow aspirates showed more than 25% blasts between 2 and 4 weeks after the first induction chemotherapy immediately received modified condi...

U Platzbecker, C Thiede, J Freiberg-Richter, C Röllig… in Bone Marrow Transplantation (2001)

Article

Double lumen port access in patients receiving allogeneic blood stem cell transplantation

We performed a prospective trial investigating the feasibility of a double lumen port access in 26 patients with hematological malignancies or solid tumors receiving either standard conditioning (n = 9, median ag...

U Platzbecker, T Illmer, M Schaich, J Freiberg-Richter… in Bone Marrow Transplantation (2001)

Article

Expression of FLIP_Long and FLIP_Short in bone marrow mononuclear and CD34+ cells in patients with myelodysplastic syndrome: correlation with apoptosis

Several apoptosis-inducing systems, including Fas/Fas ligand and TNF-related apoptosis-inducing ligand (TRAIL) and its receptors, are upregulated in myelodysplastic syndrome (MDS). FLIP (FLICE (FAS-associated ...

M Benesch, U Platzbecker, J Ward, H J Deeg, W Leisenring in Leukemia (2003)

Article

P-glycoprotein-mediated drug efflux is a resistance mechanism of chronic myelogenous leukemia cells to treatment with imatinib mesylate

Imatinib (Glivec^®, STI571) is an intracellular acting drug that demonstrates high activity against BCR-ABL-positive chronic myelogenous leukemia (CML) or acute lymphoblastic leukemia (ALL). However, many patients...

T Illmer, M Schaich, U Platzbecker, J Freiberg-Richter, U Oelschlägel… in Leukemia (2004)

Article

Graft clonogenicity and intensity of pre-treatment: factors affecting outcome of autologous peripheral hematopoietic cell transplantation in patients with acute myeloid leukemia in first remission

A total of 22 patients with acute myeloid leukemia (AML) in first complete remission receiving autologous blood stem cell transplantation (ABSCT) were investigated in order to determine factors affecting outco...

D Strodtbeck, M Bornhäuser, M Hänel, L Lerche, M Schaich… in Bone Marrow Transplantation (2005)

Article

Reduced intensity conditioning allows for up-front allogeneic hematopoietic stem cell transplantation after cytoreductive induction therapy in newly-diagnosed high-risk acute myeloid leukemia

There is substantial need to improve the outcome of patients with high-risk acute myeloid leukemia (AML). The clinical trial reported here investigated a new approach of up-front allogeneic hematopoietic stem ...

U Platzbecker, C Thiede, M Füssel, G Geissler, T Illmer, B Mohr, M Hänel… in Leukemia (2006)

Article

Imatinib mesylate does not impair the immunogenicity of human myeloid blood dendritic cells

R Wehner, M Wendisch, K Schäkel, M Bornhäuser, U Platzbecker, B Mohr, A Temme… in Leukemia (2006)

Article

Infusion of bcr/abl peptide-reactive donor T cells to achieve molecular remission of chronic myeloid leukemia after CD34⁺ selected allogeneic hematopoietic cell transplantation

M Bornhauser, C Thiede, J Babatz, J Schetelig, T Illmer, A Kiani, U Platzbecker… in Leukemia (2006)

Article

Association with the single-nucleotide polymorphism (Glu785Lys) of the granulocyte colony-stimulating factor receptor with myelodysplastic syndromes and acute myeloid leukemia with multlineage dysplasia

U Platzbecker, U Germing, U Schäkel, T Illmer, S Soucek, M Schaich, G Ehninger… in Leukemia (2006)

Article

Lenalidomide as induction therapy before allogeneic stem cell transplantation in a patient with proliferative CMML-2 and del(5q) not involving the EGR1 locus

U Platzbecker, B Mohr, M von Bonin, M Binder, J Schetelig, G Ehninger… in Leukemia (2007)

Article

Induction of Toll-like receptor 2 and 4 expression on CD4⁺ and CD8⁺ T cells in G-CSF-mobilized unrelated peripheral blood stem cell grafts during leukapheresis: impact on patient outcome

U Platzbecker, J Stoehlmacher, C Pabst, E Goekkurt, U Oelschlägel… in Leukemia (2008)

Article

Targeting mycophenolate mofetil for graft-versus-host disease prophylaxis after allogeneic blood stem cell transplantation

As low trough levels of mycophenolic acid (MPA) have been measured in recipients of allo-SCTs, we performed a pilot study targeting mycophenolate mofetil (MMF) doses according to the MPA area under the concent...

I Haentzschel, J Freiberg-Richter, U Platzbecker, A Kiani… in Bone Marrow Transplantation (2008)

Article

Treatment of refractory acute GVHD with third-party MSC expanded in platelet lysate-containing medium

Mesenchymal stem cells have been shown to mediate immunomodulatory effects. They have been used in patients with steroid-refractory acute GVHD (aGVHD), but their relevance as a therapeutic agent targeting aGVH...

M von Bonin, F Stölzel, A Goedecke, K Richter, N Wuschek… in Bone Marrow Transplantation (2009)

Article

Successful treatment of molecular relapse in NPM1-positive AML using 5-azacytidine

M Wermke, C Thiede, A Kiani, G Ehninger, M Bornhäuser, U Platzbecker in Leukemia (2010)

Article

5-Azacytidine for the treatment of patients with acute myeloid leukemia or myelodysplastic syndrome who relapse after allo-SCT: a retrospective analysis

Patients with AML or myelodysplastic syndrome who relapse after allo-SCT have a poor prognosis. In the search for novel treatment strategies for these patients, we conducted a multicenter retrospective analysi...

A Czibere, I Bruns, N Kröger, U Platzbecker, J Lind… in Bone Marrow Transplantation (2010)

Article

Haploidentical bone marrow transplantation with post-grafting cyclophosphamide: multicenter experience with an alternative salvage strategy

S Tuve, J Gayoso, C Scheid, J Radke, A Kiani, D Serrano, U Platzbecker… in Leukemia (2011)

Article

Long-term transfusion independence in del(5q) MDS patients who discontinue lenalidomide

A A N Giagounidis, A Kulasekararaj, U Germing, R Radkowski, S Haase, P Petersen… in Leukemia (2012)