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Article
ENSO at 6ka and 21ka from ocean–atmosphere coupled model simulations
We analyze how the characteristics of El Niño-Southern Oscillation (ENSO) are changed in coupled ocean–atmosphere simulations of the mid-Holocene (MH) and the Last Glacial Maximum (LGM) performed as part of th...
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Article
Past and future polar amplification of climate change: climate model intercomparisons and ice-core constraints
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Article
Past and future polar amplification of climate change: climate model intercomparisons and ice-core constraints
Climate model simulations available from the PMIP1, PMIP2 and CMIP (IPCC-AR4) intercomparison projects for past and future climate change simulations are examined in terms of polar temperature changes in compa...
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Article
Influence of diclofenac (group of nonsteroidal anti-inflammatory drugs) on fracture healing
Nonsteroidal antirheumatics (NSAR; NSAID) are often used in patients with fractured bones for analgetic reasons. This animal experiment was performed to determine the influence of NSAR on the process of fractu...
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Article
Onkologische Pharmakotherapie alter Patienten
Altern ist der Hauptrisikofaktor für die Entstehung von Krebserkrankungen. Probleme der internistisch-onkologischen Therapie können sich bei alten Patienten mit Krebserkrankungen auf Grund der altersabhängigen...
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Article
Ex vivo stimulation of renal transport of the cytostatic drugs methotrexate, cisplatin, topotecan (Hycamtin) and raltitrexed (Tomudex) by dexamethasone, T3 and EGF in intact human and rat kidney tissue and in human renal cell carcinoma
Previous experiments have shown that both in vivo and in vitro pre-treatment with various hormones increases the renal transport capacity for weak organic acids, such as PAH, in rats. The aim of the present s...
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Article
Phase I clinical and pharmacokinetic study of combination chemotherapy with topotecan and ifosfamide in patients with progressive or relapsed solid tumors.
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Article
Effects of short-term treatment with diclofenac-colestyramine on renal function and urinary prostanoid excretion in patients with type-2 diabetes
Objective. To determine the effect of short-term administration of diclofenac-colestyramine on glomerular filtration rate (GFR), renal plasma flow (RPF) and urinary excretion of prostanoids in pa...
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Chapter
Pharmakokinetik und -dynamik
Die Pharmakotherapie des geriatrisch onkologischen Patienten stellt sich für den behandelnden Arzt zumeist sehr komplex dar. Mit zunehmendem Lebensalter kommt es zu physiologischen Änderungen der Organfunktion...
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Article
RTA-Treated Ohmic Contacts To GaAs Containing WSiN Barriers
For III-V device operation at 300 °C or above ohmic contacts have to consist of multilayered systems comprising an amorphous diffusion barrier. The contact system Au/Pt/Ti/WSiN/ Au/Ge/Ni-n-GaAs (n ≈ 5.1017 cm−3) ...
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Article
Grapefruit juice inhibits 7-hydroxylation of coumarin in healthy volunteers
The effect of grapefruit juice on the urinary excretion of 7-hydroxycoumarin after oral administration of 10 mg coumarin, as an index of cytochrome P450 dependent coumarin metabolism, has been investigated in ...
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Article
Switching properties of supersymmetric quantum mechanics
In a preceding paper a dynamical form of supersymmetry breaking was considered within the framework of supersymmetric quantum mechanics. Out of these attempts a whole hierarchy of models has developed, in whic...