29 Result(s)

Article

Aflibercept in clinical practice; visual acuity, injection numbers and adherence to treatment, for diabetic macular oedema in 21 UK hospitals over 3 years

Randomised controlled trials provide evidence that a treatment works. Real world evidence is required to assess if proven treatments are effective in practice.

S. J. Talks, I. Stratton, T. Peto, A. Lotery, U. Chakravarthy, H. Eleftheriadis… in Eye (2022)

Article

An overview of the clinical applications of optical coherence tomography angiography

Optical coherence tomography angiography (OCTA) has emerged as a novel, non-invasive imaging modality that allows the detailed study of flow within the vascular structures of the eye. Compared to conventional ...

A C S Tan, G S Tan, A K Denniston, P A Keane, M Ang, D Milea, U Chakravarthy… in Eye (2018)

Article

Real-world experience with 0.2 μg/day fluocinolone acetonide intravitreal implant (ILUVIEN) in the United Kingdom

To compare safety outcomes and visual function data acquired in the real-world setting with FAME study results in eyes treated with 0.2 μg/day fluocinolone acetonide (FAc).

C Bailey, U Chakravarthy, A Lotery, G Menon, J Talks in Eye (2017)

Article

Clinical features and long-term progression of reticular pseudodrusen in age-related macular degeneration: findings from a multicenter cohort

To determine whether reticular pseudodrusen (RPD) confer a long-term increased risk of progression to late age-related macular degeneration (AMD) in the fellow eye of patients with unilateral wet-AMD.

J Q Gil, J P Marques, R Hogg, C Rosina, M L Cachulo, A Santos, G Staurenghi… in Eye (2017)

Article

The UK Neovascular AMD Database Report 3: inter-centre variation in visual acuity outcomes and establishing real-world measures of care

International variations in visual acuity (VA) outcomes of eyes treated for neovascular age-related macular degeneration (nAMD) are well-documented, but intra-country inter-centre regional variations are not k...

G Liew, A Y Lee, J Zarranz-Ventura, I Stratton, C Bunce, U Chakravarthy, C S Lee… in Eye (2016)

Article

Optical coherence tomography angiography in paracentral acute middle maculopathy secondary to central retinal vein occlusion

To report the clinical course and the optical coherence tomography angiography (OCTA) findings of patients presenting with paracentral acute middle maculopathy (PAMM) and central retinal vein occlusion (CRVO).

G Casalino, M Williams, C McAvoy, F Bandello, U Chakravarthy in Eye (2016)

Article

Stellate nonhereditary idiopathic foveomacular retinoschisis concomitant to exudative maculopathies

To report the clinical course of patients presenting with stellate nonhereditary idiopathic foveomacular retinoschisis (SNIFR) concomitant with exudative maculopathies.

G Casalino, M Upendran, F Bandello, U Chakravarthy in Eye (2016)

Article

The design and implementation of a study to investigate the effectiveness of community vs hospital eye service follow-up for patients with neovascular age-related macular degeneration with quiescent disease

Standard treatment for neovascular age-related macular degeneration (nAMD) is intravitreal injections of anti-VEGF drugs. Following multiple injections, nAMD lesions often become quiescent but there is a high ...

J Taylor, L J Scott, C A Rogers, A Muldrew, D O'Reilly, S Wordsworth, N Mills… in Eye (2016)

Article

Erratum: Defining response to anti-VEGF therapies in neovascular AMD

Correction to: Eye (2015) 29, 721–731; doi:10.1038/eye.2015.48; published online 17 April 2015 Since the online publication of the above article, the authors have noted that the name of the ninth author was pu...

W M Amoaku, U Chakravarthy, R Gale, M Gavin, F Ghanchi, J Gibson, S Harding… in Eye (2015)

Article

Defining response to anti-VEGF therapies in neovascular AMD

The introduction of anti-vascular endothelial growth factor (anti-VEGF) has made significant impact on the reduction of the visual loss due to neovascular age-related macular degeneration (n-AMD). There are si...

W M Amoaku, U Chakravarthy, R Gale, M Gavin, F Ghanchi, J Gibson, S Harding… in Eye (2015)

Article

Erratum: The Royal College of Ophthalmologists Guidelines on AMD: Executive Summary

Correction to: Eye (2013) 27, 1429–1431; doi:10.1038/eye.2013.233; published online 25 October 2013 Since the online publication of the above article, the authors have noted that the members of the AMD Guideli...

U Chakravarthy, M Williams in Eye (2013)

Article

The Royal College of Ophthalmologists Guidelines on AMD: Executive Summary

U Chakravarthy, M Williams in Eye (2013)

Article

Modelling of longitudinal outcomes with highly skewed distributions: applications in the IVAN trial

R Nash, L Scott, U Chakravarthy, SP Harding, BC Reeves, CA Rogers in Trials (2013)

Article

Exudative AMD subtypes and eligibility for treatment with ranibizumab

To ascertain the proportion of patients with neovascular age-related macular degeneration (AMD) eligible for intravitreal treatment with monoclonal antibodies to vascular endothelial growth factor, on the basi...

S George, C Cooke, U Chakravarthy in Eye (2010)

Article

Introduction of photodynamic therapy for the treatment of neovascular age-related macular degeneration: tracking a moving target

Objectives To identify changes in referral and treatment patterns of neovascular age-related macular degeneration with photodynamic therapy (PDT) within ophthalmology units in NHS hospitals and assess how beliefs...

B Foot, R Foy, U Chakravarthy, R Wormald in Eye (2003)

Article

Molecular genetics of microvascular disease in diabetic retinopathy

Diabetic retinopathy is a sight-threatening complication of the retinal microvasculature. While important environmental factors have been clearly identified as influencing its development, increasing evidence ...

K M Warpeha, U Chakravarthy in Eye (2003)

Article

A new health technology: where is the consensus on a clinically worthwhile benefit?

Aim New therapies are often introduced into the NHS prior to full evaluation, leading to inequities in provision. Uncertainty exists regarding the value of photodynamic therapy in the treatment of neovascular age...

B Foot, R Foy, U Chakravarthy, R Wormald in Eye (2002)

Article

Plasma levels of endothelin-1 in diabetic retinopathy in pregnancy

Purpose Raised circulating levels of the potent vasoconstrictor endothelin-1 (ET-1) have been demonstrated in diabetes and pregnancyinduced hypertension. Pregnant women with diabetic retinopathy are known to be a...

R M Best, R Hayes, U Chakravarthy, D B Archer, D R Hadden in Eye (1999)

Article

Dinucleotide repeat polymorphisms in EDN1 and NOS3 are not associated with severe diabetic retinopathy in type 1 or type 2 diabetes

Purpose Endothelin-1, and constitutive endothelial nitric oxide synthase, have been implicated in the pathogenesis of diabetic retinopathy. We therefore screened polymorphisms within the genes encoding these two ...

K M Warpeha, F Ah-Fat, S Harding, C C Patterson, W Xu, P M Hart, U Chakravarthy… in Eye (1999)