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  1. No Access

    Article

    Neue medikamentöse Therapieansätze bei chronischer Herzinsuffizienz

    Die Herzinsuffizienz ist eine Erkrankung mit hoher Prävalenz und Inzidenz. Neue Therapieansätze werden benötigt, um das Auftreten einer Herzinsuffizienz zu verhindern und die hohe Morbidität und Mortalität der...

    Prof. Dr. T. Kempf, U. Bavendiek, J. Bauersachs in Der Internist (2017)

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    Chapter and Conference Paper

    Effect of inotropic interventions on the force-frequency relation in the human heart

    In severe human heart failure, an increase in frequency of Stimulation is accompanied by a reduced force of contraction in vivo and in vitro. This contrasts the findings in nonfailing human hearts. To investig...

    U. Bavendiek, K. Brixius, G. Münch, C. Zobel… in Heart rate as a determinant of cardiac fun… (2000)

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    Article

    Frequency dependent force generation correlates with sarcoplasmic calcium ATPase activity in human myocardium

    Objective: In congestive heart failure both a decreased function of the sarcoplasmic Ca2+-ATPase and a negative force-frequency relationship have been shown. This study aimed to investigate a possible relationsh...

    K. Frank, B. Bölck, U. Bavendiek, R.H.G. Schwinger in Basic Research in Cardiology (1998)

  4. No Access

    Article

    Effect of inotropic interventions on the force-frequency relation in the human heart

    In severe human heart failure, an increase in frequency of stimulation is accompanied by a reduced force of contraction in vivo and in vitro. This contrasts the findings in nonfailing human hearts. To invest...

    U. Bavendiek, K. Brixius, G. Münch, C. Zobel… in Basic Research in Cardiology (1998)

  5. No Access

    Article

    Sarcoplasmic reticulum Ca2+ATPase and phospholamban mRNA and protein levels in end-stage heart failure due to ischemic or dilated cardiomyopathy

    Abnormalities in intracellular Ca2+ handling play a crucial role in the pathogenesis of heart failure. The reduced capacity of failing human myocardium to restore low resting Ca2+ levels during diastole has been ...

    M. Flesch, R. H. G. Schwinger, P. Schnabel, F. Schiffer… in Journal of Molecular Medicine (1996)

  6. No Access

    Article

    Altered inotropism in the failing human myocardium

    β-Adrenoreceptor-cAMP-dependent inotropic interventions lose their effectiveness depending on the degree of myocardial failure. This blunted effect of β-adrenoreceptor-dependent stimulation might be due to a d...

    U. Bavendiek, K. Brixius, K. Frank, H. Reuter, M. Pietsch… in Basic Research in Cardiology (1996)