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  1. Article

    Open Access

    An otoprotective role for the apoptosis inhibitor protein survivin

    Hearing impairment caused by ototoxic insults, such as noise or gentamicin is a worldwide health problem. As the molecular circuitries involved are not yet resolved, current otoprotective therapies are rather ...

    S K Knauer, U-R Heinrich, C Bier, N Habtemichael, D Docter… in Cell Death & Disease (2010)

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  2. No Access

    Article

    Possible roles of nitric oxide in the physiology and pathophysiology of the guinea pig cochlea

    Two nitric oxide synthase isoforms (NOS-I and NOS-III) are present in the mammalian cochlea, and many regulatory functions of the inner ear could be mediated by NO. In this study, cochlear potentials and immu...

    K. Gosepath, U. R. Heinrich, U. Ecke… in European Archives of Oto-Rhino-Laryngology (2000)

  3. No Access

    Article

    Immunoelectron microscopic localization of nitric oxide synthase III in the guinea pig organ of Corti

    Nitric oxide synthase III (NOS III) was identified in the guinea pig cochlea on an ultrastructural level using a post-embedding immunolabeling procedure. Ultrathin sections of London Resin (LR) White-embedded...

    U.-R. Heinrich, J. Maurer, K. Gosepath… in European Archives of Oto-Rhino-Laryngology (1998)

  4. No Access

    Article

    Use of electron spectroscopic imaging to determine element composition of the melanin granules in the stria vascularis of the guinea pig

    Electron spectroscopic imaging (ESI) was used to analyze the element content of melanin granules in the stria vascularis seen in ultrathin sections of Spurr-embedded cochleae of the guinea pig. To determine e...

    U.-R. Heinrich, J. Maurer, W. Mann in European Archives of Oto-Rhino-Laryngology (1998)

  5. No Access

    Article

    Electron microscopic localization of nitric oxide I synthase in the organ of Corti of the guinea pig

    Nitric oxide synthase (NOS) activity has been detected previously in the mammalian cochlea at a light microscopic level. Here we present results of electron microscopic analysis for post-embedding immunoreacti...

    U. -R. Heinrich, J. Maurer, K. Gosepath… in European Archives of Oto-Rhino-Laryngology (1997)

  6. No Access

    Article

    Alteration of loosely bound calcium in the guinea pig organ of Corti after treatment with diltiazem as calcium channel blocker

    After oral administration of the organic calcium channel blocker diltiazem to guinea pigs for 7 days, calcium ions were precipitated with potassium antimonate in the cochleae. The spatial distribution of the p...

    U. -R. Heinrich, J. Maurer, W. Mann in European Archives of Oto-Rhino-Laryngology (1997)

  7. No Access

    Article

    Influence of a new chemical crosslink system on the morphology and crystallite size of nylon-12

    Special polyamide chains of desirable structure were polymerized such that they already contained reactive sites at the chain ends. The degree of crosslinking is determined by the chain structure and the amoun...

    H. G. Bader, H. F. E. Schnell, D. Göritz, U. -R. Heinrich… in Journal of Materials Science (1992)

  8. No Access

    Article

    Calcium-binding sites in the inner ear after pure-tone stimulation

    Five guinea pigs were exposed to an interrupted 90 dB SPL pure tone of 3.2 kHz for a total application time of 5 min. Following sound application all animals were decapitated and the cochleae were removed. Aft...

    J. Maurer, W. Mann, U. R. Heinrich in European Archives of Oto-Rhino-Laryngology (1991)

  9. No Access

    Article

    Fine-structural and chemical analyses on inner and outer sheath of the cyanobacteriumGloeothece sp. PCC 6909

    Cells of the unicellular cyanobacteriumGloeothece sp. PCC 6909 are surrounded by an inner (enclosing 1–2 cells) and an outer (enclosing cell groups) sheath. Using conventional Epon-embedding in combination with r...

    B. Tease, U. J. Jürgens, J. R. Golecki, U. -R. Heinrich… in Antonie van Leeuwenhoek (1991)

  10. No Access

    Article

    Ultrastructural localization of Ca2+-binding sites in the middle ear mucosa of the rat

    Cations were precipitated with potassiumpyroantimonate in the middle ear mucosa of the rat and the distribution of the formed precipitates was studied by electron microscopy. The precipitate density in various...

    M. C. Karatay, W. Mann, U. -R. Heinrich in European Archives of Oto-Rhino-Laryngology (1990)

  11. No Access

    Article

    Ultrastructural localization of Ca2+-binding sites in the spiral limbus, the stria vascularis and Reissner's membrane of the guinea pig

    Cations were precipitated with potassium antimonate in the cochlea of the guinea pig and electron microscopy was used to analyze the distribution of the formed reaction products. Differences in precipitate den...

    U. -R. Heinrich, W. Mann in Archives of oto-rhino-laryngology (1988)

  12. No Access

    Article

    Cation distribution in the organ of Corti of the guinea pig

    Cations were precipitated with potassium antimonate in the cochlea of the guinea pig and the distribution of the formed precipitates was studied by electron microscopy. The precipitate density in different cel...

    W. Mann, U. -R. Heinrich in Archives of oto-rhino-laryngology (1988)

  13. No Access

    Chapter and Conference Paper

    Element specific electron microscopy of polymeric materials

    Electron Spectroscopic Imaging (ESI) was performed on a polyethylene specimen and on the poly(styrene-b-2-vinylpyridine) blockcopolymer to obtain information about the microstructural organization. Polyethylen...

    M. Kunz, U.-R. Heinrich, M. Möller, H.-J. Cantow in Dispersed Systems (1988)

  14. No Access

    Article

    Abnormal organization of ovarian follicles in the mutant l(1)su(f)mad-ts ofDrosophila melanogaster

    The morphology of ovarian follicles in the temperature-sensitive female-sterile mutantl(1)su(f)mad-ts has been studied by means of light and electron microscopy. As the follicle cells gradually degenerate at the ...

    H. O. Gutzeit, U. -R. Heinrich in Experientia (1981)