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Article
Allogeneic stem cell transplantation after conditioning with treosulfan, etoposide and cyclophosphamide for patients with ALL: a phase II-study on behalf of the German Cooperative Transplant Study Group and ALL Study Group (GMALL)
TBI-based preparative regimens are considered as standard conditioning therapy for allogeneic stem cell transplantation (AHSC) in patients with ALL. We investigated toxicity and efficacy of a non-TBI-based reg...
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Article
Anatomic features of glioblastoma and their potential impact on survival
Many reports on glioblastoma multiforme discuss the prognostic impact of anatomical features such as cysts, necrotic changes, extent of edema or subependymal spread of tumor cells. In the present study, we exa...
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Article
Kontralaterale Biopsie beim Hodentumor
Bei Patienten mit einem Keimzelltumor (KZT) des Hodens gilt die kontralaterale Biopsie als Instrument zur Früherkennung von Zweittumoren im Gegenhoden. Trotz wissenschaftlich hoher Evidenz besteht internationa...
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Article
Allogeneic hematopoietic SCT in patients with AML following treosulfan/fludarabine conditioning
An alternative reduced-toxicity conditioning regimen for allogeneic transplantation, based on treosulfan and fludarabine, has recently been identified. The safety and efficacy of this new conditioning regimen ...
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Article
Retrospective analysis of treosulfan-based conditioning in comparison with standard conditioning in patients with myelodysplastic syndrome
Myelodysplastic syndromes (MDSs) often occur in older adults with significant comorbidities. Therefore, a reduced-toxicity conditioning regimen may be more suitable than standard conditioning regimens before a...
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Article
Open AccessTallness is associated with risk of testicular cancer: evidence for the nutrition hypothesis
The pathogenesis of testicular germ cell tumours (GCTs) is potentially influenced by high-energy nutrition during infancy. As adult height is a proxy for childhood nutrition, we investigated the role of nutrit...
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Article
Vergleich der Effektivität der Langzeitinstillation mit Mitomycin C gegen Kurzzeitprophylaxen mit MMC oder Bacillus Calmette-Guerin
Die adjuvante Instillationstherapie mit Chemo- bzw. Immuntherapeutika ist integraler Bestandteil in der Behandlung nicht muskelinvasiver Blasenkarzinome. In der Auswahl des Medikaments sowie in der optimalen T...
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Article
Dose-escalated treosulphan in combination with cyclophosphamide as a new preparative regimen for allogeneic haematopoietic stem cell transplantation in patients with an increased risk for regimen-related complications
Treosulphan has recently demonstrated antileukaemic activity and potent haematopoietic stem cell toxicity. Dose-escalated treosulphan (3 × 12 or 3 × 14 g/m2) combined with cyclophosphamide (Cy) was chosen for a n...
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Article
Clinical epidemiology of testicular germ cell tumors
Clinical epidemiology is sometimes called the basic science of clinical medicine. In terms of the pathogenesis of testicular germ cell tumors (GCTs), clinical epidemiology analyzes suspected risk factors. The ...
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Article
Senkung des Rezidivrisikos oberflächlicher Harnblasenkarzinome mittels 5-Aminolävulinsäure-induzierter Fluoreszenzdiagnostik
Im Rahmen einer unizentrischen randomisierten prospektiven Phase-III-Studie wurde untersucht, ob die transurethrale Resektion (TUR) von oberflächlichen Blasentumoren mittels 5-Aminolävulinsäure- (5-ALA-)induzi...
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Article
Epidemiologie der testikulären Keimzelltumoren
Die testikulären Keimzelltumoren des Hodens haben derzeit eine Inzidenz von ca. 7,6 Neuerkrankungen pro 100.000 Männer pro Jahr in Deutschland; die Mortalität liegt zurzeit bei unter 1 pro 100.00...
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Chapter
Clinical and Pathohistological Prognosticators
The clinical T1-T2 prostatic carcinoma is a heterogeneous tumor in respect to pathologic stage and outcome. Tumor heterogeneity can be fairly well predicted using classification and regression tree analysis (C...
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Article
A validated strategy to select patients for a nerve-sparing radical prostatectomy
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Chapter and Conference Paper
Plakoglobin Downregulation als Indikator einer ungünstigen Prognose bei Patienten mit resektablem Ösophaguskarzinom
Das Ösophaguskarzinom stellt einen sehr aggressiven Tumor mit schlechter Prognose dar, da es bereits frühzeitig zu einer Tumorzelldissemination kommt [1]. Eine wichtige Voraussetzung für diese Dissemination is...
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Article
Inverse correlation of interleukin-6 with soluble interleukin-6 receptor after transplantation of bone marrow or peripheral blood stem cells
The relationship between interleukin-6 (IL-6) and the soluble interleukin-6 receptor (sIL-6R) was analyzed in 1481 serum samples of 82 patients after bone marrow or peripheral blood cell transplantation. The c...
