Skip to main content

6 Result(s)

within Tze Mun Loo Remove this filter

and

  1. Article

    Open Access

    RNaseH2A downregulation drives inflammatory gene expression via genomic DNA fragmentation in senescent and cancer cells

    Cellular senescence caused by oncogenic stimuli is associated with the development of various age-related pathologies through the senescence-associated secretory phenotype (SASP). SASP is mediated by the activ...

    Sho Sugawara, Ryo Okada, Tze Mun Loo, Hisamichi Tanaka… in Communications Biology (2022)

    Download PDF (3098 KB) View Article

  2. Article

    Open Access

    Hepatocyte growth factor derived from senescent cells attenuates cell competition-induced apical elimination of oncogenic cells

    Cellular senescence and cell competition are important tumor suppression mechanisms that restrain cells with oncogenic mutations at the initial stage of cancer development. However, the link between cellular s...

    Nanase Igarashi, Kenichi Miyata, Tze Mun Loo, Masatomo Chiba… in Nature Communications (2022)

    Download PDF (3125 KB) View Article

  3. Article

    Open Access

    A BET family protein degrader provokes senolysis by targeting NHEJ and autophagy in senescent cells

    Although cellular senescence acts primarily as a tumour suppression mechanism, the accumulation of senescent cells in vivo eventually exerts deleterious side effects through inflammatory/tumour-promoting factor s...

    Masahiro Wakita, Akiko Takahashi, Osamu Sano, Tze Mun Loo… in Nature Communications (2020)

    Download PDF (3437 KB) View Article

  4. Article

    Open Access

    Downregulation of cytoplasmic DNases is implicated in cytoplasmic DNA accumulation and SASP in senescent cells

    Accumulating evidence indicates that the senescence-associated secretory phenotype (SASP) contributes to many aspects of physiology and disease. Thus, controlling the SASP will have tremendous impacts on our h...

    Akiko Takahashi, Tze Mun Loo, Ryo Okada, Fumitaka Kamachi… in Nature Communications (2018)

    Download PDF (2633 KB) View Article

  5. Article

    Correction: Corrigendum: Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome

    Nature 499, 97–101 (2013); doi:10.1038/nature12347 In this Letter, the forename of author Masahira Hattori was spelled incorrectly as ‘Masahisa’. It has been corrected in the HTML and PDF versions of the manus...

    Shin Yoshimoto, Tze Mun Loo, Koji Atarashi, Hiroaki Kanda, Seidai Sato… in Nature (2014)

    Download PDF (81 KB) View Article

  6. No Access

    Article

    Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome

    Obesity is shown in a mouse model of liver cancer to strongly enhance tumorigenesis; a high fat diet alters the composition of intestinal bacteria, leading to more production of the metabolite DCA which, proba...

    Shin Yoshimoto, Tze Mun Loo, Koji Atarashi, Hiroaki Kanda, Seidai Sato… in Nature (2013)