8 Result(s)
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Article
Structural basis of inter-protein electron transfer for nitrite reduction in denitrification
Nitrous oxide (N2O) is a greenhouse gas that is an intermediate during the biological process known as 'denitrification'. Copper-containing nitrite reductase (CuNIR) produces a precursor for N2O by catalysing the...
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Open AccessTargeting BIG3–PHB2 interaction to overcome tamoxifen resistance in breast cancer cells
The acquisition of endocrine resistance is a common obstacle in endocrine therapy of patients with oestrogen receptor-α (ERα)-positive breast tumours. We previously demonstrated that the BIG3–PHB2 complex has ...
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Article
Open AccessEffects of Chronic Low-Dose Radiation on Human Neural Progenitor Cells
The effects of chronic low-dose radiation on human health have not been well established. Recent studies have revealed that neural progenitor cells are present not only in the fetal brain but also in the adult...
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Article
Open AccessA RuBisCO-mediated carbon metabolic pathway in methanogenic archaea
Two enzymes are considered to be unique to the photosynthetic Calvin–Benson cycle: ribulose-1,5-bisphosphate carboxylase/oxygenase (RuBisCO), responsible for CO2 fixation, and phosphoribulokinase (PRK). Some arch...
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Article
Open AccessVagus nerve stimulation even after injury ameliorates cisplatin-induced nephropathy via reducing macrophage infiltration
The efficacy of prior activation of an anti-inflammatory pathway called the cholinergic anti-inflammatory pathway (CAP) through vagus nerve stimulation (VNS) has been reported in renal ischemia-reperfusion inj...
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Article
Open AccessNovel neutralizing human monoclonal antibodies against tetanus neurotoxin
Tetanus is a fatal disease caused by tetanus neurotoxin (TeNT). TeNT is composed of a light chain (Lc) and a heavy chain, the latter of which is classified into two domains, N-terminus Hn and C-terminus Hc. Se...
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Article
Open AccessEpoxidized graphene grid for highly efficient high-resolution cryoEM structural analysis
Functionalization of graphene is one of the most important fundamental technologies in a wide variety of fields including industry and biochemistry. We have successfully achieved a novel oxidative modification...
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Open AccessStructures of a FtsZ single protofilament and a double-helical tube in complex with a monobody
FtsZ polymerizes into protofilaments to form the Z-ring that acts as a scaffold for accessory proteins during cell division. Structures of FtsZ have been previously solved, but detailed mechanistic insights ar...
