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Article
End-of-treatment 18[F]-FDG PET can predict early progression in patients receiving bendamustine-rituximab for follicular lymphoma in first relapse: a prospective West Japan hematology Study Group (W-JHS) NHL01 trial
Response determined by 18[F]-fluoro-2-deoxy-d-glucose (18F-FDG) positron emission tomography (PET)–CT after induction therapy can predict progression-free survival (PFS) in follicular lymphoma (FL). However, litt...
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Article
Open AccessThick slab crust with rough basement weakens interplate coupling in the western Nankai Trough
The westernmost Nankai Trough, southwest Japan, exhibits a rapid along-strike reduction in plate coupling in the proximity to the subducting Kyushu-Palau ridge. Yet how and to what extent the ridge subduction ...
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Article
Open AccessUsing brain structural neuroimaging measures to predict psychosis onset for individuals at clinical high-risk
Machine learning approaches using structural magnetic resonance imaging (sMRI) can be informative for disease classification, although their ability to predict psychosis is largely unknown. We created a model ...
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Article
Open AccessSubcortical volumetric alterations in four major psychiatric disorders: a mega-analysis study of 5604 subjects and a volumetric data-driven approach for classification
Differential diagnosis is sometimes difficult in practical psychiatric settings, in terms of using the current diagnostic system based on presenting symptoms and signs. The creation of a novel diagnostic syste...
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Article
Measurement of microscopic rheological properties in oil-in-water emulsions via spherical nanoindentation
Techniques for evaluating the micromechanical properties of materials are crucial in engineering fields. In previous studies, many researchers have utilized atomic force microscopy (AFM) to address these subje...
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Article
Open AccessCerebral cortical structural alteration patterns across four major psychiatric disorders in 5549 individuals
According to the operational diagnostic criteria, psychiatric disorders such as schizophrenia (SZ), bipolar disorder (BD), major depressive disorder (MDD), and autism spectrum disorder (ASD) are classified bas...
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Article
Open AccessTectonic evolution of the Nootka fault zone and deformation of the shallow subducted Explorer plate in northern Cascadia as revealed by earthquake distributions and seismic tomography
At the northern Cascadia subduction zone, the subducting Explorer and Juan de Fuca plates interact across a transform deformation zone, known as the Nootka fault zone (NFZ). This study continues the Seafloor E...
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Article
Open AccessFault geometry of M6-class normal-faulting earthquakes in the outer trench slope of Japan Trench from ocean bottom seismograph observations
Since the 2011 Mw 9.0 Tohoku-oki earthquake, intra-plate normal-faulting earthquakes, including several M7-class earthquakes, have occurred in the outer trench slope area from the trench to the outer rise alon...
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Article
Open AccessPreterm toddlers have low nighttime sleep quality and high daytime activity
A number of studies have been made on the sleep characteristics of children born preterm in an attempt to develop methods to address the sleep problems commonly observed among such children. However, the repor...
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Article
Open AccessNeuroanatomical heterogeneity and homogeneity in individuals at clinical high risk for psychosis
Individuals at Clinical High Risk for Psychosis (CHR-P) demonstrate heterogeneity in clinical profiles and outcome features. However, the extent of neuroanatomical heterogeneity in the CHR-P state is largely u...
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Article
Observation of OW · WO emulsion coating film formed by doctor blade applicator
In this study, OW · WO emulsions, which are similar to the product formulation, were used for thin film deposition at high speeds. The evaluation of the developed thin films showed that the shear process durin...
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Article
Open AccessPrecocious puberty in a case of Simpson–Golabi–Behmel syndrome with a de novo 240-kb deletion including GPC3
Here, we report a Japanese patient with Simpson–Golabi–Behmel syndrome involving a de novo 240-kb deletion including a part of GPC3. The patient showed pre- and postnatal macrosomia associated with coarse face, m...
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Article
Open AccessDiagnosis of SLC25A46-related pontocerebellar hypoplasia in two siblings with fulminant neonatal course: role of postmortem CT and whole genomic analysis: a case report
Pontocerebellar hypoplasia (PCH) is increasingly known as a degenerative disease rather than simple “hypoplasia”. At least 21 disease-causing genes have been identified for PCH so far. Because PCH is very hete...
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Article
Increased expression of TCF3, transcription factor 3, is a defense response against methylmercury toxicity in mouse neuronal C17.2 cells
Methylmercury is an environmental pollutant that induces potent neurotoxicity. We previously identified transcription factor 3 (TCF3) as a transcription factor that is activated in the brains of mice treated w...
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Article
Open AccessSleep maturation influences cognitive development of preterm toddlers
Our recent study on full-term toddlers demonstrated that daytime nap properties affect the distribution ratio between nap and nighttime sleep duration in total sleep time but does not affect the overall total ...
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Article
Restructuring time and deformation history effect in restructuring process after yield behavior of α-gel O/W emulsion
An interesting aspect of the yielding behavior of soft matter is the repetitive nature of the yielding phenomenon. In creams and gels, once the yielding phenomenon occurs, the structure recovers after a certai...
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Article
Open AccessReduced cortical thickness of the paracentral lobule in at-risk mental state individuals with poor 1-year functional outcomes
Although widespread cortical thinning centered on the fronto-temporal regions in schizophrenia has been reported, the findings in at-risk mental state (ARMS) patients have been inconsistent. In addition, it re...
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Article
Open AccessAnomalous brain gyrification patterns in major psychiatric disorders: a systematic review and transdiagnostic integration
Anomalous patterns of brain gyrification have been reported in major psychiatric disorders, presumably reflecting their neurodevelopmental pathology. However, previous reports presented conflicting results of ...
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Article
Combination of clofarabine, etoposide, and cyclophosphamide in adult relapsed/refractory acute lymphoblastic leukemia: a phase 1/2 dose-escalation study by the Japan Adult Leukemia Study Group
This phase 1/2 study aimed to identify the maximum tolerated dose, the recommended phase 2 dose (RP2D), and efficacy of the clofarabine, etoposide, and cyclophosphamide combination regimen in adult patients wi...
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Article
Open AccessRare genetic variants in the gene encoding histone lysine demethylase 4C (KDM4C) and their contributions to susceptibility to schizophrenia and autism spectrum disorder
Dysregulation of epigenetic processes involving histone methylation induces neurodevelopmental impairments and has been implicated in schizophrenia (SCZ) and autism spectrum disorder (ASD). Variants in the gen...
