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    Retinoic acid induces polarizing activity but is unlikely to be a morphogen in the chick limb bud

    RETINOIC acid is a putative morphogen in limb formation in the chick and other vertebrates1-5. In chick limb formation, it is thought that retinoic acid is released from the zone of polarizing activity (ZPA) and ...

    Sumihare Noji, Tsutomu Nohno, Eiki Koyama, Kohki Muto, Kazuhiko Ohyama… in Nature (1991)