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    Combined BRAFV600E and MEK blockade for BRAFV600E-mutant gliomas

    BRAFV600E is a common finding in glioma (about 10–60% depending on histopathologic subclassification). BRAFV600E monotherapy shows modest preclinical efficacy against BRAFV600E gliomas and also induces adverse se...

    Jie Zhang, Tsun-Wen Yao, Rintaro Hashizume, Sujatmi Hariono… in Journal of Neuro-Oncology (2017)