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  1. Chapter

    Flow of Information Underlying a Tactile Decision in Mice

    Motor planning allows us to conceive, plan, and initiate skilled motor behaviors. Motor planning involves activity distributed widely across the cortex. How this activity dynamically comes together to guide mo...

    Nuo Li, Zengcai V. Guo, Tsai-Wen Chen… in Micro-, Meso- and Macro-Dynamics of the Br… (2016)

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  2. Article

    Open Access

    Neuronal Representation of Ultraviolet Visual Stimuli in Mouse Primary Visual Cortex

    The mouse has become an important model for understanding the neural basis of visual perception. Although it has long been known that mouse lens transmits ultraviolet (UV) light and mouse opsins have absorptio...

    Zhongchao Tan, Wenzhi Sun, Tsai-Wen Chen, Douglas Kim, Na Ji in Scientific Reports (2015)

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  3. No Access

    Article

    A motor cortex circuit for motor planning and movement

    Activity in motor cortex predicts specific movements seconds before they occur, but how this preparatory activity relates to upcoming movements is obscure. We dissected the conversion of preparatory activity t...

    Nuo Li, Tsai-Wen Chen, Zengcai V. Guo, Charles R. Gerfen, Karel Svoboda in Nature (2015)

  4. No Access

    Article

    Multiplexed aberration measurement for deep tissue imaging in vivo

    An adaptive optics method using multiplexed light measurement and modulation in multiple pupil segments improves structural and functional in vivo imaging over large volumes in strongly scattering mouse brain wit...

    Chen Wang, Rui Liu, Daniel E Milkie, Wenzhi Sun, Zhongchao Tan… in Nature Methods (2014)

  5. No Access

    Article

    Optimized ratiometric calcium sensors for functional in vivo imaging of neurons and T lymphocytes

    A collection of improved FRET-based calcium biosensors, called Twitch sensors, is described. Twitches have a reduced number of calcium binding sites per sensor and display high sensitivity in in vivo imaging expe...

    Thomas Thestrup, Julia Litzlbauer, Ingo Bartholomäus, Marsilius Mues… in Nature Methods (2014)

  6. No Access

    Article

    Ultrasensitive fluorescent proteins for imaging neuronal activity

    Fluorescent calcium sensors are widely used to image neural activity. Using structure-based mutagenesis and neuron-based screening, we developed a family of ultrasensitive protein calcium sensors (GCaMP6) that...

    Tsai-Wen Chen, Trevor J. Wardill, Yi Sun, Stefan R. Pulver, Sabine L. Renninger… in Nature (2013)

  7. No Access

    Article

    An optimized fluorescent probe for visualizing glutamate neurotransmission

    A single-wavelength genetically encoded sensor of extracellular glutamate is reported. The sensor—iGluSnFR—is bright and photostable under both one- and two-photon illumination and is shown to work for in vivo im...

    Jonathan S Marvin, Bart G Borghuis, Lin Tian, Joseph Cichon… in Nature Methods (2013)