Page
%P
-
Article
Open AccessEarly mucosal events promote distinct mucosal and systemic antibody responses to live attenuated influenza vaccine
Compared to intramuscular vaccines, nasally administered vaccines have the advantage of inducing local mucosal immune responses that may block infection and interrupt transmission of respiratory pathogens. Liv...
-
Article
Open AccessCellular and molecular features of COVID-19 associated ARDS: therapeutic relevance
The severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection can be asymptomatic or cause a disease (COVID-19) characterized by different levels of severity. The main cause of severe COVID-19 and...
-
Article
Open AccessBiomarkers for Acute Respiratory Distress syndrome and prospects for personalised medicine
Acute lung injury (ALI) affects over 10% of patients hospitalised in critical care, with acute respiratory distress syndrome (ARDS) being the most severe form of ALI and having a mortality rate in the region o...
-
Article
Open AccessNasal inflammation and its response to local glucocorticoid regular treatment in patients with persistent non-allergic rhinitis: a pilot study
The pathogenesis of non-allergic rhinitis (NAR) is still largely unknown. Furthermore, it is unclear whether there is a correlation between the effect of nasal glucocorticoids on nasal inflammation and on nasa...
-
Article
The safety and side effects of monoclonal antibodies
Molecular engineering has enabled the fine-tuning of monoclonal antibody (mAb) function to enhance their effects and to minimize immunogenicity and side effect...
-
Article
Open AccessNon-specific interstitial pneumonia in cigarette smokers: a CT study
The goal of this study was to seek indirect evidence that smoking is an aetiological factor in some patients with non-specific interstitial pneumonia (NSIP). Ten current and eight ex-smokers with NSIP were com...
-
Article
Antagonism of the prostaglandin D2 receptors DP1 and CRTH2 as an approach to treat allergic diseases
Immunological activation of mast cells is an important trigger in the cascade of inflammatory events that lead to the manifestation of allergic diseases. Prost...
-
Article
Open AccessA prospective study of decline in fat free mass and skeletal muscle strength in chronic obstructive pulmonary disease
Skeletal muscle depletion is an important complication of chronic obstructive pulmonary disease (COPD) but little prospective data exists about the rate at which it occurs and the factors that promote its deve...
-
Book
-
Chapter
New drugs for COPD based on advances in pathophysiology
There is a pressing need to develop new treatments for chronic obstructive pulmonary disease (COPD), as no currently available drug has been shown to reduce the relentless progression of this disease. Furtherm...
-
Chapter
Computed tomography (CT) scans in COPD
Structural information about the lungs has been obtainable for over one hundred years through imaging techniques. Cross-sectional computed tomography (CT) provides a great advance over conventional radiography...
-
Protocol
Measurement of Granulocyte Pharmacodynamics in Whole Blood by Flow Cytometry
During the Phase I/II assessment of new therapies with the potential to suppress eosinophil and neutrophil inflammation, there is a need to assess the peripheral blood pharmacokinetic (PK) and pharmacodynamic ...
