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Article
Biocatalytic, enantioenriched primary amination of tertiary C–H bonds
Intermolecular functionalization of tertiary C–H bonds to construct fully substituted stereogenic carbon centres represents a formidable challenge: without the assistance of directing groups, state-of-the-art ...
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Article
Biocatalytic, stereoconvergent alkylation of (Z/E)-trisubstituted silyl enol ethers
The selective conversion of mixtures of Z/E alkenes into chiral products is a synthetic challenge. Biocatalytic strategies can transform isomeric alkenes into stereopure compounds, but enzymes typically convert o...
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Article
Open AccessData-driven design of new chiral carboxylic acid for construction of indoles with C-central and C–N axial chirality via cobalt catalysis
Challenging enantio- and diastereoselective cobalt-catalyzed C–H alkylation has been realized by an innovative data-driven knowledge transfer strategy. Harnessing the statistics of a related transformation as ...
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Article
C–H activation
Transition metal-catalysed C–H activation has emerged as an increasingly powerful platform for molecular syntheses, enabling applications to natural product syntheses, late-stage modification, pharmaceutical i...
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Article
Open AccessLate-stage peptide C–H alkylation for bioorthogonal C–H activation featuring solid phase peptide synthesis
Methods for the late-stage diversification of structurally complex peptides hold enormous potential for advances in drug discovery, agrochemistry and pharmaceutical industries. While C–H arylations emerged for...
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Article
Versatile and robust C–C activation by chelation-assisted manganese catalysis
C–H activation has been recognized as an increasingly viable tool in molecular sciences, but organometallic C–C activation is scarce, and limited to precious and toxic metal catalysts. Herein, we disclose vers...
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Article
Open AccessNickel-catalyzed reductive thiolation and selenylation of unactivated alkyl bromides
Chalcogen-containing compounds have received considerable attention because of their manifold applications in agrochemicals, pharmaceuticals, and material science. While many classical methods have been develo...
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Article
Open AccessRuthenium(II)-catalysed remote C–H alkylations as a versatile platform to meta-decorated arenes
The full control of positional selectivity is of prime importance in C–H activation technology. Chelation assistance served as the stimulus for the development of a plethora of ortho-selective arene functionaliza...
