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Article
Open AccessCalcium-to-phosphorus releasing ratio affects osteoinductivity and osteoconductivity of calcium phosphate bioceramics in bone tissue engineering
Calcium phosphate (Ca-P) bioceramics, including hydroxyapatite (HA), biphasic calcium phosphate (BCP), and beta-tricalcium phosphate (β-TCP), have been widely used in bone reconstruction. Many studies have foc...
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Article
Open AccessCorrection: In vitro expansion impaired the stemness of early passage mesenchymal stem cells for treatment of cartilage defects
Following the publication of this article, the authors noticed that Fig. 5c in the original manuscript is incorrect due to an error in image handling during the creation of the figure. Specifically, the image ...
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Article
Open AccessIn vitro culture expansion impairs chondrogenic differentiation and the therapeutic effect of mesenchymal stem cells by regulating the unfolded protein response
In vitro expansion of mesenchymal stem cells (MSCs) has been implicated in loss of multipotency, leading to impaired chondrogenic potential and an eventual therapeutic effect, as reported in our previous study...
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Article
Open AccessIn vitro expansion impaired the stemness of early passage mesenchymal stem cells for treatment of cartilage defects
In vitro cultured autologous mesenchymal stem cells (MSCs) within passage 5 have been approved for clinical application in stem cell-based treatment of cartilage defects. However, their chondrogenic potential has...
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Article
Open AccessNerve growth factor from Chinese cobra venom stimulates chondrogenic differentiation of mesenchymal stem cells
Growth factors such as transforming growth factor beta1 (TGF-β1), have critical roles in the regulation of the chondrogenic differentiation of mesenchymal stem cells (MSCs), which promote cartilage repair. Howeve...
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Article
Open AccessCombination therapy with vancomycin-loaded calcium sulfate and vancomycin-loaded PMMA in the treatment of chronic osteomyelitis
Chronic post-traumatic and postoperative osteomyelitis is a refractory disease which results in significant morbidity and mortality. The effect of combination therapy with vancomycin-loaded calcium sulfate and...
