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Article
Open AccessSafety of pulsed field ablation in more than 17,000 patients with atrial fibrillation in the MANIFEST-17K study
Pulsed field ablation (PFA) is an emerging technology for the treatment of atrial fibrillation (AF), for which pre-clinical and early-stage clinical data are suggestive of some degree of preferentiality to myo...
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Article
Open AccessLeadless Cardiac Pacing: New Horizons
Since the introduction of transvenous cardiac pacing leads, pacemaker system design has remained similar for several decades. Progressive miniaturisation of electronic circuitry and batteries has enabled a sma...
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Article
Open AccessBeyond pulmonary vein isolation for persistent atrial fibrillation: sequential high-resolution map** to guide ablation
We aimed to evaluate whether outcomes with ablation in persistent (PsAF) and long-standing persistent (LsPsAF) AF can be improved beyond what can be achieved with pulmonary vein isolation (PVI) alone, using in...
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Article
Open AccessBiomarkers as predictors of recurrence of atrial fibrillation post ablation: an updated and expanded systematic review and meta-analysis
A high proportion of patients undergoing catheter ablation (CA) for atrial fibrillation (AF) experience recurrence of arrhythmia. This meta-analysis aims to identify pre-ablation serum biomarker(s) associated ...
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Article
Open AccessThe impact of ultra-high-density map** on long-term outcome after catheter ablation of ventricular tachycardia
Ultra-high-density (UHD) map** can improve scar area detection and fast activation map** in patients undergoing catheter ablation of ventricular tachycardia (VT). The aim of the present study was to compar...
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Article
Open AccessEvaluation of a pilot immunization curriculum to meet competency training needs of medical residents
Vaccination is the most cost-effective medical intervention known to prevent morbidity and mortality. However, data are limited on the effectiveness of residency programs in delivering immunization knowledge a...
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Chapter
Cardiac Pacing in Adults
The heart is served by intrinsic, efficient and coordinated electrical activation provided by its specialised conduction system. The conduction system can be damaged, requiring the provision of pacing to maint...
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Article
Open AccessEffectiveness of text messaging interventions on prevention, detection, treatment, and knowledge outcomes for sexually transmitted infections (STIs)/HIV: a systematic review and meta-analysis
Rates of STIs continue to rise worldwide, and novel evidence-based interventions such as text messaging aimed at improving client services are needed. We conducted a meta-analysis to evaluate text messaging to...
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Chapter and Conference Paper
Atrial Scar Segmentation via Potential Learning in the Graph-Cut Framework
Late Gadolinium Enhancement Magnetic Resonance Imaging (LGE MRI) emerges as a routine scan for patients with atrial fibrillation (AF). However, due to the low image quality automating the quantification and an...
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Chapter and Conference Paper
Discriminative Consistent Domain Generation for Semi-supervised Learning
Deep learning based task systems normally rely on a large amount of manually labeled training data, which is expensive to obtain and subject to operator variations. Moreover, it does not always hold that the m...
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Article
Open AccessScreening for chlamydia and/or gonorrhea in primary health care: protocol for systematic review
Chlamydia trachomatis and Neisseria gonorrhoeae are the most commonly reported sexually transmitted infections in Canada. Existing national guidance on screening for these infections was not based on a systematic...
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Article
Open AccessResource use and clinical outcomes in patients with atrial fibrillation with ablation versus antiarrhythmic drug treatment
The objective of our study was to compare resource use and clinical outcomes among atrial fibrillation (AF) patients who underwent catheter ablation versus antiarrhythmic drug (AAD) treatment.
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Article
Open AccessCatheter Ablation versus Thoracoscopic Surgical Ablation in Long Standing Persistent Atrial Fibrillation (CASA-AF): study protocol for a randomised controlled trial
Atrial fibrillation is the commonest arrhythmia which raises the risk of heart failure, thromboembolic stroke, morbidity and death. Pharmacological treatments of this condition are focused on heart rate contro...
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Chapter and Conference Paper
Adversarial and Perceptual Refinement for Compressed Sensing MRI Reconstruction
Deep learning approaches have shown promising performance for compressed sensing-based Magnetic Resonance Imaging. While deep neural networks trained with mean squared error (MSE) loss functions can achieve hi...
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Chapter and Conference Paper
Atrial Fibrosis Quantification Based on Maximum Likelihood Estimator of Multivariate Images
We present a fully-automated segmentation and quantification of the left atrial (LA) fibrosis and scars combining two cardiac MRIs, one is the target late gadolinium-enhanced (LGE) image, and the other is an a...
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Chapter and Conference Paper
Multiview Two-Task Recursive Attention Model for Left Atrium and Atrial Scars Segmentation
Late Gadolinium Enhanced Cardiac MRI (LGE-CMRI) for detecting atrial scars in atrial fibrillation (AF) patients has recently emerged as a promising technique to stratify patients, guide ablation therapy and pr...
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Article
Open AccessCatheter ablation for AF improves global thrombotic profile and enhances fibrinolysis
Patients with atrial fibrillation (AF) are at increased risk of thrombotic events despite oral anticoagulation (OAC). Radiofrequency catheter ablation (RFCA) can restore and maintain sinus rhythm (SR) in patie...
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Chapter and Conference Paper
Segmenting Atrial Fibrosis from Late Gadolinium-Enhanced Cardiac MRI by Deep-Learned Features with Stacked Sparse Auto-Encoders
The late gadolinium-enhanced (LGE) MRI technique is a well-validated method for fibrosis detection in the myocardium. With this technique, the altered wash-in and wash-out contrast agent kinetics in fibrotic a...
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Article
A low-dose, dual-phase cardiovascular CT protocol to assess left atrial appendage anatomy and exclude thrombus prior to left atrial intervention
Assessment of the left atrial appendage (LAA) for thrombus and anatomy is important prior to atrial fibrillation (AF) ablation and LAA exclusion. The use of cardiovascular CT (CCT) to detect LAA thrombus has b...
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Article
Open AccessRapid automatic segmentation of abnormal tissue in late gadolinium enhancement cardiovascular magnetic resonance images for improved management of long-standing persistent atrial fibrillation
Atrial fibrillation (AF) is the most common heart rhythm disorder. In order for late Gd enhancement cardiovascular magnetic resonance (LGE CMR) to ameliorate the AF management, the ready availability of the ac...
