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  1. Article

    Open Access

    Systematic elucidation of neuron-astrocyte interaction in models of amyotrophic lateral sclerosis using multi-modal integrated bioinformatics workflow

    Cell-to-cell communications are critical determinants of pathophysiological phenotypes, but methodologies for their systematic elucidation are lacking. Herein, we propose an approach for the Systematic Elucida...

    Vartika Mishra, Diane B. Re, Virginia Le Verche… in Nature Communications (2020)

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  2. Article

    Open Access

    Age-related neurodegenerative disease associated pathways identified in retinal and vitreous proteome from human glaucoma eyes

    Glaucoma is a chronic disease that shares many similarities with other neurodegenerative disorders of the central nervous system. This study was designed to evaluate the association between glaucoma and other ...

    Mehdi Mirzaei, Veer B. Gupta, Joel M. Chick, Todd M. Greco, Yunqi Wu… in Scientific Reports (2017)

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  3. No Access

    Article

    Systematic discovery of structural elements governing stability of mammalian messenger RNAs

    Secondary structures, or pairing of complementary sequences within RNA, can regulate the binding of proteins that affect transcript stability, splicing, localization, and translation; a computational approach ...

    Hani Goodarzi, Hamed S. Najafabadi, Panos Oikonomou, Todd M. Greco, Lisa Fish… in Nature (2012)