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    Assessment of urinary mephenytoin metrics to phenotype for CYP2C19 and CYP2B6 activity

    (S)-Mephenytoin is selectively metabolised to (S)-4′-hydroxymephenytoin by CYP2C19. The urinary excretion of 4′-hydroxymephenytoin reflects the activity of individual enzymes. We evaluated fractioned urinary c...

    Tobias Klaassen, Alexander Jetter… in European Journal of Clinical Pharmacology (2008)