21 Result(s)

Article

Efficacy and safety of human umbilical cord-derived mesenchymal stem cells in the treatment of refractory immune thrombocytopenia: a prospective, single arm, phase I trial

Patients with refractory immune thrombocytopenia (ITP) frequently encounter substantial bleeding risks and demonstrate limited responsiveness to existing therapies. Umbilical cord-derived mesenchymal stem cell...

Yunfei Chen, Yanmei Xu, Ying Chi, Ting Sun… in Signal Transduction and Targeted Therapy (2024)

Article

Eosinophils promote pulmonary matrix destruction and emphysema via Cathepsin L

Patients with chronic obstructive pulmonary disease (COPD) who exhibit elevated blood eosinophil levels often experience worsened lung function and more severe emphysema. This implies the potential involvement...

**a Xu, Tao Yu, Lingling Dong, Rainer Glauben… in Signal Transduction and Targeted Therapy (2023)

Article

SIRT6 is an epigenetic repressor of thoracic aortic aneurysms via inhibiting inflammation and senescence

Thoracic aortic aneurysms (TAAs) develop asymptomatically and are characterized by dilatation of the aorta. This is considered a life-threating vascular disease due to the risk of aortic rupture and without ef...

Yang-Nan Ding, Ting-Ting Wang, Shuang-Jie Lv… in Signal Transduction and Targeted Therapy (2023)

Article

N6-methyladenosine reader YTHDF2 promotes multiple myeloma cell proliferation through EGR1/p21^cip1/waf1/CDK2-Cyclin E1 axis-mediated cell cycle transition

Multiple myeloma (MM) is the second most common hematological malignancy. N6-methyladenosine (m⁶A) is the most abundant RNA modification. YTH domain-containing family protein 2 (YTHDF2) recognizes m⁶A-cotaining R...

Rui Liu, Jiyu Miao, Yachun Jia, Guangyao Kong, Fei Hong, Fangmei Li, Meng Zhai… in Oncogene (2023)

Article

Immunological and metabolic characteristics of the Omicron variants infection

The Omicron variants of SARS-CoV-2, primarily authenticated in November 2021 in South Africa, has initiated the 5th wave of global pandemics. Here, we systemically examined immunological and metabolic characte...

Jiejie Geng, Xu Yang, Kun Wang, Ke Wang… in Signal Transduction and Targeted Therapy (2023)

Article

Phosphorylated NFS1 weakens oxaliplatin-based chemosensitivity of colorectal cancer by preventing PANoptosis

Metabolic enzymes have an indispensable role in metabolic reprogramming, and their aberrant expression or activity has been associated with chemosensitivity. Hence, targeting metabolic enzymes remains an attra...

**-Fei Lin, Pei-Shan Hu, Yi-Yu Wang… in Signal Transduction and Targeted Therapy (2022)

Article

Thrombin induces ACSL4-dependent ferroptosis during cerebral ischemia/reperfusion

Ischemic stroke represents a significant danger to human beings, especially the elderly. Interventions are only available to remove the clot, and the mechanism of neuronal death during ischemic stroke is still...

Qing-zhang Tuo, Yu Liu, … in Signal Transduction and Targeted Therapy (2022)

Article

CD147 antibody specifically and effectively inhibits infection and cytokine storm of SARS-CoV-2 and its variants delta, alpha, beta, and gamma

SARS-CoV-2 mutations contribute to increased viral transmissibility and immune escape, compromising the effectiveness of existing vaccines and neutralizing antibodies. An in-depth investigation on COVID-19 pat...

Jiejie Geng, Liang Chen, Yufeng Yuan, Ke Wang… in Signal Transduction and Targeted Therapy (2021)

Article

Correction: C-terminal truncated HBx initiates hepatocarcinogenesis by downregulating TXNIP and reprogramming glucose metabolism

Yu Zhang, Qian Yan, Lanqi Gong, Hang Xu, Beilei Liu, **aona Fang, Dandan Yu… in Oncogene (2021)

Article

FTO downregulation mediated by hypoxia facilitates colorectal cancer metastasis

Fat mass and obesity-associated protein (FTO), an N6-methyladenosine (m⁶A) demethylase, participates in tumor progression and metastasis in many malignancies, but its role in colorectal cancer (CRC) is still uncl...

Dan-Yun Ruan, Ting Li, Ying-Nan Wang, Qi Meng, Yang Li, Kai Yu, Min Wang… in Oncogene (2021)

Article

CD147 receptor is essential for TFF3-mediated signaling regulating colorectal cancer progression

Major gaps in understanding the molecular mechanisms of colorectal cancer (CRC) progression and intestinal mucosal repair have hampered therapeutic development for gastrointestinal disorders. Trefoil factor 3 ...

Hong-Yong Cui, Shi-Jie Wang, Fei Song, Xu Cheng… in Signal Transduction and Targeted Therapy (2021)

Article

Recent progress in targeted delivery vectors based on biomimetic nanoparticles

Over the past decades, great interest has been given to biomimetic nanoparticles (BNPs) since the rise of targeted drug delivery systems and biomimetic nanotechnology. Biological vectors including cell membran...

Li Chen, Weiqi Hong, Wenyan Ren, Ting Xu… in Signal Transduction and Targeted Therapy (2021)

Article

Safety and efficacy of meplazumab in healthy volunteers and COVID-19 patients: a randomized phase 1 and an exploratory phase 2 trial

Recent evidence suggests that CD147 serves as a novel receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Blocking CD147 via anti-CD147 antibody could suppress the in vitro SAR...

Huijie Bian, Zhao-Hui Zheng, Ding Wei… in Signal Transduction and Targeted Therapy (2021)

Article

Correction to: PD1 inhibitor in combination with 5-azacytidine and low-dose DLI for the successful treatment of AML patients who relapsed after transplantation

A Correction to this paper has been published: https://doi.org/10.1038/s41409-021-01218-9

Chong-Sheng Qian, **ao Ma, ** Wang, Ting-**g Wang… in Bone Marrow Transplantation (2021)

Article

Ferroptosis: mechanisms and links with diseases

Ferroptosis is an iron-dependent cell death, which is different from apoptosis, necrosis, autophagy, and other forms of cell death. The process of ferroptotic cell death is defined by the accumulation of letha...

Hong-fa Yan, Ting Zou, Qing-zhang Tuo, Shuo Xu… in Signal Transduction and Targeted Therapy (2021)

Article

C-terminal truncated HBx initiates hepatocarcinogenesis by downregulating TXNIP and reprogramming glucose metabolism

Chronic hepatitis B virus (HBV) infection is strongly associated with the initiation and development of hepatocellular carcinoma (HCC). However, the genetic alterations and pathogenesis mechanisms remain signi...

Yu Zhang, Qian Yan, Lanqi Gong, Hang Xu, Beilei Liu, **aona Fang, Dandan Yu… in Oncogene (2021)

Article

VDR–SOX2 signaling promotes colorectal cancer stemness and malignancy in an acidic microenvironment

The acidic tumor microenvironment provides an energy source driving malignant tumor progression. Adaptation of cells to an acidic environment leads to the emergence of cancer stem cells. The expression of the ...

Pei-Shan Hu, Ting Li, **-Fei Lin… in Signal Transduction and Targeted Therapy (2020)

Article

Application of exosomes as liquid biopsy in clinical diagnosis

Liquid biopsy refers to the sampling and molecular analysis of the biofluids of circulating tumor cells, extracellular vesicles, nucleic acids, and so forth. Exosomes are small extracellular vesicles with size...

Biting Zhou, Kailun Xu, ** Zheng, Ting Chen… in Signal Transduction and Targeted Therapy (2020)

Article

Combined inhibition of Notch and FLT3 produces synergistic cytotoxic effects in FLT3/ITD⁺ acute myeloid leukemia

Internal tandem duplication (ITD) mutations of FMS-like tyrosine kinase-3 (FLT3) are the most frequent genetic alterations in acute myeloid leukemia (AML) and predict a poor prognosis. FLT3 tyrosine kinase inh...

Dan Li, Tongjuan Li, Zhen Shang, Lei Zhao… in Signal Transduction and Targeted Therapy (2020)

Article

Regulation of estrogen signaling and breast cancer proliferation by an ubiquitin ligase TRIM56

Breast cancer ranks no. 1 in women cancer worldwide, while 60–70% are estrogen receptor alpha positive. The estrogen selective modulators, such as tamoxifen, become the effective drugs for controlling ER alpha...

Min Xue, Kai Zhang, Kun Mu, Juntao Xu, Huijie Yang, Yun Liu, Beibei Wang… in Oncogenesis (2019)