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Article
A DNA origami device spatially controls CD95 signalling to induce immune tolerance in rheumatoid arthritis
DNA origami is capable of spatially organizing molecules into sophisticated geometric patterns with nanometric precision. Here we describe a reconfigurable, two-dimensional DNA origami with geometrically patte...
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Article
Open AccessA novel small molecule inhibitor of CD73 triggers immune-mediated multiple myeloma cell death
CD73 is the key ectoenzyme involved in the generation of AMP-derived adenosine, which contributes to immunosuppression in the MM BM milieu.
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Article
Open AccessExercise is inversely associated with functional dyspepsia among a sample of Chinese male armed police recruits
There is no study evaluating the association between exercise and functional dyspepsia (FD) based on the Rome IV criteria. We aimed to investigate the prevalence of FD and evaluate the association between exer...
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Article
Open AccessThe synergistic effect of EMT regulators and m6A modification on prognosis-related immunological signatures for ovarian cancer
Recently, there has been growing interest among researchers in exploring the effects of epithelial-mesenchymal transformation (EMT) or N6-Methyladenosine (m6A) modification regulators on tumor development. How...
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Article
Open AccessSizes and shapes of perivascular spaces surrounding murine pial arteries
Flow of cerebrospinal fluid (CSF) through brain perivascular spaces (PVSs) is essential for the clearance of interstitial metabolic waste products whose accumulation and aggregation is a key mechanism of patho...
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Article
Open AccessMeasurements of cerebrospinal fluid production: a review of the limitations and advantages of current methodologies
Cerebrospinal fluid (CSF) is an essential and critical component of the central nervous system (CNS). According to the concept of the “third circulation” originally proposed by Cushing, CSF is mainly produced ...
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Article
Open AccessVan-mediated self-aggregating photothermal agents combined with multifunctional magnetic nickel oxide nanoparticles for precise elimination of bacterial infections
Building a novel and efficient photothermal antibacterial nanoplatform is a promising strategy for precise bacterial elimination. Herein, a nanocomposite NiO NPs@AuNPs@Van (NAV) for selective MRSA removal was ...
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Article
Open AccessIdentification and validation of ecto-5' nucleotidase as an immunotherapeutic target in multiple myeloma
Interaction of plasmacytoid dendritic cells (pDCs) with multiple myeloma (MM) cells, T- or NK-effector cells in the bone marrow (BM) microenvironment induces tumor cell growth, as well as inhibits innate and a...
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Article
Open AccessThe Effects of Limosilactobacillus reuteri LR-99 Supplementation on Body Mass Index, Social Communication, Fine Motor Function, and Gut Microbiome Composition in Individuals with Prader–Willi Syndrome: a Randomized Double-Blinded Placebo-Controlled Trial
Prader–Willi syndrome (PWS) is a rare genetic disorder associated with developmental delay, obesity, and neuropsychiatric comorbidities. Limosilactobacillus reuteri (Lactobacillus reuteri, Lact. reuteri) has demo...
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Article
Correction: Preclinical validation of Alpha-Enolase (ENO1) as a novel immunometabolic target in multiple myeloma
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Article
Targeting ubiquitin-specific protease-7 in plasmacytoid dendritic cells triggers anti-myeloma immunity
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Article
Age-and Region-Dependent Disposition of Raloxifene in Rats
Raloxifene undergoes extensive glucuronidation in the gastrointestinal (GI) tract and the liver. However, the impact of age on raloxifene disposition has never been studied. The purpose of this paper is to det...
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Article
Rational design of smart adsorbent equipped with a sensitive indicator via ligand exchange: A hierarchical porous mixed-ligand MOF for simultaneous removal and detection of Hg2+
The increasing accumulation of toxic mercury species in water environment has posed a serious health threat worldwide, making it inevitable to develop the versatile materials to achieve efficient prevention an...
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Article
Proteomic analysis identifies mechanism(s) of overcoming bortezomib resistance via targeting ubiquitin receptor Rpn13
Our prior study showed that inhibition of 19S proteasome-associated ubiquitin receptor Rpn13 can overcome bortezomib resistance in MM cells. Here, we performed proteomic analysis of Rpn13 inhibitor (RA190)-tre...
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Open AccessIdentification of novel anti-tumor therapeutic target via proteomic characterization of ubiquitin receptor ADRM1/Rpn13
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Article
Principal Slip Zone determination in the Wenchuan earthquake Fault Scientific Drilling project-hole 1: considering the Bayesian discriminant function
Accurate determination of the Principal Slip Zone (PSZ) of earthquake fault zones is a key task of earthquake Fault Scientific Drilling for future earthquake control. The fault zone structure of Wenchuan earth...
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Article
Open AccessCorrection to: Longitudinal transcriptomic characterization of viral genes in HSV-1 infected tree shrew trigeminal ganglia
An amendment to this paper has been published and can be accessed via the original article.
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Article
Mechanical loading induces HIF-1α expression in chondrocytes via YAP
To investigate the role of YAP in cyclic mechanical stress induced up-regulation of HIF-1α in rat cartilage chondrocytes.
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Article
Open AccessDifferential diagnosis between hepatic alveolar echinococcosis and intrahepatic cholangiocarcinoma with conventional ultrasound and contrast-enhanced ultrasound
Misclassifications of hepatic alveolar echinococcosis (HAE) as intrahepatic cholangiocarcinoma (ICC) may lead to inappropriate treatment strategies. The aim of this study was to explore the differential diagno...
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Article
Open AccessLongitudinal transcriptomic characterization of viral genes in HSV-1 infected tree shrew trigeminal ganglia
Following acute infection, Herpes Simplex virus-1 (HSV-1) establishes lifelong latency and recurrent reactivation in the sensory neurons of trigeminal ganglia (TG). Infected tree shrew differs from mouse and s...
