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Article
Treatment contentment and preference of patients undergoing intravitreal anti-VEGF therapy
The aim of this study is to investigate patients´ treatment preference between the pro re nata (PRN) and treat and extend (T&E) regimens and their feelings and contentment undergoing intravitreal injections (I...
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Article
Open AccessInitiale Diagnostik und Indikationsstellung zur Anti-Vascular-Endothelial Growth-Factor-Therapie bei Netzhauterkrankungen
Das ORCA-Modul der nichtinterventionellen OCEAN-Studie untersucht den Einsatz der bildgebenden Diagnostik in der klinischen Versorgung bei Patienten unter VEGF(„vascular endothelial growth factor“)-Hemmer-Beha...
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Article
Open AccessGWAS study using DNA pooling strategy identifies association of variant rs4910623 in OR52B4 gene with anti-VEGF treatment response in age-related macular degeneration
Pooled DNA based GWAS to determine genetic association of SNPs with visual acuity (VA) outcome in anti-vascular endothelial growth factor (anti-VEGF) treated neovascular age-related macular degeneration (nAMD)...
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Article
Open AccessA Novel Complotype Combination Associates with Age-Related Macular Degeneration and High Complement Activation Levels in vivo
The complement system is the first line of defense against foreign intruders and deregulation of this system has been described in multiple diseases. In age-related macular degeneration (AMD), patients have hi...
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Article
A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants
Iris Heid, Gonçalo Abecasis, Sudha Iyengar and colleagues report the results of a large genome-wide association meta-analysis of macular degeneration based on over 43,000 subjects. They identify 16 new risk lo...
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Article
Open AccessA Candidate Gene Association Study Identifies DAPL1 as a Female-Specific Susceptibility Locus for Age-Related Macular Degeneration (AMD)
Age-related macular degeneration (AMD) is the leading cause of blindness among white caucasians over the age of 50 years with a prevalence rate expected to increase markedly with an anticipated increase in th...
