9 Result(s)

Article

Frailty, Outcomes, Recovery and Care Steps of Critically Ill Patients (FORECAST): a prospective, multi-centre, cohort study

Frailty is common in critically ill patients but the timing and optimal method of frailty ascertainment, trajectory and relationship with care processes remain uncertain. We sought to elucidate the trajectory ...

John Muscedere, Sean M. Bagshaw, Michelle Kho, Sangeeta Mehta… in Intensive Care Medicine (2024)

Article

Knowledge translation tools to guide care of non-intubated patients with acute respiratory illness during the COVID-19 Pandemic

Providing optimal care to patients with acute respiratory illness while preventing hospital transmission of COVID-19 is of paramount importance during the pandemic; the challenge lies in achieving both goals s...

David Leasa, Paul Cameron, Kimia Honarmand, Tina Mele, Karen J. Bosma in Critical Care (2021)

Article

The role of miR-711 in cardiac cells in response to oxidative stress and its biogenesis: a study on H9C2 cells

Oxidative stress results in cell apoptosis/death and plays a detrimental role in disease development and progression. Stressors alter the miRNA expression profile and miRNAs play a role in the cell response to...

Duo Zhao, Hao Zheng, Adam Greasley, Fengjun Ling… in Cellular & Molecular Biology Letters (2020)

Article

Growth Differentiation Factor-15 Deficiency Augments Inflammatory Response and Exacerbates Septic Heart and Renal Injury Induced by Lipopolysaccharide

Septic acute kidney injury (AKI) and myocardial dysfunction are leading causes of mortality with no accepted method of therapy. In this study we demonstrate the role of growth differentiating factor 15 (GDF15)...

Palida Abulizi, Neruja Loganathan, Duo Zhao, Tina Mele, Yixin Zhang… in Scientific Reports (2017)

Article

Induction of acute lung inflammation in mice with hemorrhagic shock and resuscitation: role of HMGB1

Hemorrhagic shock and resuscitation (HS/R) can induce multiple organ failure which is associated with high mortality. The lung is an organ commonly affected by the HS/R. Acute lung injury is a major cause of d...

Raymond LC Kao, Xuemei Xu, Anargyros Xenocostas, Neil Parry… in Journal of Inflammation (2014)

Article

A robust scoring system to evaluate sepsis severity in an animal model

The lack of a reliable scoring system that predicts the development of septic shock and death precludes comparison of disease and/or treatment outcomes in animal models of sepsis. We developed a murine sepsis ...

Bradly Shrum, Ram V Anantha, Stacey X Xu, Marisa Donnelly… in BMC Research Notes (2014)

Article

Histamine-neurotrophin-3 interactions in cultured rat astrocytes

Tina Mele, Damijana M Jurič, Marija Čarman-Kržan in BMC Pharmacology (2009)