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  1. Article

    Correction: A Tangeretin Derivative Inhibits the Growth of Human Prostate Cancer LNCaP Cells by Epigenetically Restoring p21 Gene Expression and Inhibiting Cancer Stem-like Cell Proliferation

    Guor-Jien Wei, Yen-Hsiang Chao, Yen-Chen Tung, Tien-Yuan Wu… in The AAPS Journal (2023)

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  2. Article

    Open Access

    Clinical impact of tetracyclines and/or proton pump inhibitors on the efficacy of epidermal growth factor receptor inhibitors in non-small cell lung cancer: a retrospective cohort study

    This retrospective cohort study examined the impact of tetracyclines (TCs) and proton pump inhibitors (PPIs) alone or in combination on the efficacy of epidermal growth factor receptor tyrosine kinase inhibito...

    Hui-Hsia Hsieh, Tien-Yuan Wu, Chi-Hua Chen, Yu-Hung Kuo, Mann-Jen Hour in BMC Cancer (2023)

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    Article

    A Tangeretin Derivative Inhibits the Growth of Human Prostate Cancer LNCaP Cells by Epigenetically Restoring p21 Gene Expression and Inhibiting Cancer Stem-like Cell Proliferation

    Prostate cancer ranks the second in incidence and the fifth in mortality cancer in male globally. Citrus polymethoxyflavonoids (PMFs), such as tangeretin (PMF1), have been found to exhibit various biological a...

    Guor-Jien Wei, Yen-Hsiang Chao, Yen-Chen Tung, Tien-Yuan Wu… in The AAPS Journal (2019)

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    Article

    Pharmacokinetics and pharmacodynamics of 3,3′-diindolylmethane (DIM) in regulating gene expression of phase II drug metabolizing enzymes

    3,3′-Diindolylmethane (DIM) has been investigated as a potential anti-cancer chemopreventive agent in many preclinical and clinical studies. In this study, we sought to characterize the pharmacokinetics of DIM...

    Tien-Yuan Wu, Ying Huang, Chengyue Zhang… in Journal of Pharmacokinetics and Pharmacody… (2015)

  5. No Access

    Article

    Epigenetic Modifications of Nrf2 by 3,3′-diindolylmethane In Vitro in TRAMP C1 Cell Line and In Vivo TRAMP Prostate Tumors

    3,3′-diindolylmethane (DIM) is currently being investigated in many clinical trials including prostate, breast, and cervical cancers and has been shown to possess anticancer effects in several in vivo and in vitr...

    Tien-Yuan Wu, Tin Oo Khor, Zheng-Yuan Su, Constance Lay-Lay Saw… in The AAPS Journal (2013)

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    Article

    Epigenetic CpG Demethylation of the Promoter and Reactivation of the Expression of Neurog1 by Curcumin in Prostate LNCaP Cells

    Curcumin (CUR), a major bioactive polyphenolic component from turmeric curry, Curcuma longa, has been shown to be a potent anti-cancer phytochemical with well-established anti-inflammatory and anti-oxidative stre...

    Limin Shu, Tin Oo Khor, Jong-Hun Lee, Sarandeep S. S. Boyanapalli… in The AAPS Journal (2011)

  7. No Access

    Article

    Anti-inflammatory/Anti-oxidative Stress Activities and Differential Regulation of Nrf2-Mediated Genes by Non-Polar Fractions of Tea Chrysanthemum zawadskii and Licorice Glycyrrhiza uralensis

    Accumulating evidence from epidemiological studies indicates that chronic inflammation and oxidative stress play critical roles in neoplastic development. The aim of this study was to investigate the anti-infl...

    Tien-Yuan Wu, Tin Oo Khor, Constance Lay Lay Saw, Stephanie C. Loh… in The AAPS Journal (2011)