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  1. No Access

    Article

    Residential environmental exposures and other characteristics associated with detectable PAH-DNA adducts in peripheral mononuclear cells in a population-based sample of adult females

    The detection of polycyclic aromatic hydrocarbon (PAH)-DNA adducts in human lymphocytes may be useful as a surrogate end point for individual cancer risk prediction. In this study, we examined the relationship...

    Sumitra Shantakumar, Marilie D Gammon… in Journal of Exposure Science & Environmenta… (2005)

  2. No Access

    Chapter

    Polycyclic Aromatic Hydrocarbon-DNA Adducts in Smokers and Their Relationship to Micronutrient Levels and Glutathione-S-Transferase M1 Genotype

    Sixty-three male cigarette smokers were entered into a cross-sectional study to determine whether inverse associations existed between polycyclic aromatic hydrocarbon (PAH)-DNA adduct levels and intake/serum l...

    Ricardo A. Grinberg-Funes, Vishwa N. Singh… in Nutrients in Cancer Prevention and Treatme… (1995)

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    Article

    Molecular and genetic damage in humans from environmental pollution in Poland

    EXTREME environmental pollution such as that found in the highly industrialized Silesian region of Poland has been associated with increased risk of cancer and adverse reproductive outcomes1,2. Among the most pre...

    Frederica P. Perera, Kari Hemminki, Ewa Gryzbowska, Grazyna Motykiewicz… in Nature (1992)

  4. No Access

    Chapter

    Biological Monitoring of Exposure to Polycyclic Aromatic Hydrocarbons

    Methods are now available for the sensitive detection and quantitation of carcinogen-DNA adducts which do not depend upon radiolabeled carcinogens. These methods are essential for the measurement of adducts in...

    Regina M. Santella, Yu **g Zhang… in Anticarcinogenesis and Radiation Protectio… (1991)

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    Chapter

    Monitoring Human Exposure to Environmental Carcinogens

    One of the long range goal of research in chemical carcinogenesis is the identification of individuals at increased risk of cancer development. Cancer is a multistep, multistage process in which many factors e...

    Regina M. Santella, Yu **g Zhang, Tie Lan Young… in Biological Reactive Intermediates IV (1991)

  6. No Access

    Chapter

    Immunological Methods for the Detection of Polycyclic Aromatic Hydrocarbon-DNA and Protein Adducts

    Sensitive immunological methods are now available for the detection and quantitation of carcinogen-DNA and protein adducts. Both monoclonal and polyclonal antibodies have been developed against DNA modified by...

    Regina M. Santella, You Li, Yu **g Zhang… in Genetic Toxicology of Complex Mixtures (1990)

  7. No Access

    Chapter

    Immunologic Methods for the Detection of Carcinogen Adducts in Humans

    Immunologic methods are now available for the sensitive detection and quantitation of carcinogen-DNA adducts. Monoclonal and polyclonal antibodies have been developed against a number of specific adducts as we...

    Regina M. Santella, **ao Yen Yang… in DNA Damage and Repair in Human Tissues (1990)