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  1. No Access

    Article

    A p53–phosphoinositide signalosome regulates nuclear AKT activation

    The tumour suppressor p53 and PI3K–AKT pathways have fundamental roles in the regulation of cell growth and apoptosis, and are frequently mutated in cancer. Here, we show that genotoxic stress induces nuclear ...

    Mo Chen, Suyong Choi, Tianmu Wen, Changliang Chen, Narendra Thapa… in Nature Cell Biology (2022)

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    Protocol

    Assessing In Situ Phosphoinositide–Protein Interactions Through Fluorescence Proximity Ligation Assay in Cultured Cells

    Proximity ligation assay (PLA) is a well-established method for detecting in situ interactions between two epitopes with high resolution and specificity. Notably, PLA is not only a robust method for studying p...

    Mo Chen, Hudson T. Horn, Tianmu Wen, Vincent L. Cryns… in Phosphoinositides (2021)

  3. No Access

    Article

    Phosphatidylinositol 3-kinase signalling is spatially organized at endosomal compartments by microtubule-associated protein 4

    The canonical model of agonist-stimulated phosphatidylinositol 3-kinase (PI3K)–Akt signalling proposes that PI3K is activated at the plasma membrane, where receptors are activated and phosphatidylinositol-4,5-...

    Narendra Thapa, Mo Chen, Hudson T. Horn, Suyong Choi, Tianmu Wen… in Nature Cell Biology (2020)

  4. Article

    Open Access

    The Specificity of EGF-Stimulated IQGAP1 Scaffold Towards the PI3K-Akt Pathway is Defined by the IQ3 motif

    Epidermal growth factor receptor (EGFR) and its downstream phosphoinositide 3-kinase (PI3K) pathway are commonly deregulated in cancer. Recently, we have shown that the IQ motif-containing GTPase-activating pr...

    Mo Chen, Suyong Choi, Oisun Jung, Tianmu Wen, Christina Baum… in Scientific Reports (2019)

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