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Article
Open AccessA longitudinal evaluation of oxidative stress - mitochondrial dysfunction - ferroptosis genes in anthracycline-induced cardiotoxicity
Antineoplastic medications, including doxorubicin, idarubicin, and epirubicin, have been found to adversely affect the heart due to oxidative stress - mitochondrial dysfunction - ferroptosis (ORMFs), which act...
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Article
Open AccessNavigation performance analysis of Earth–Moon spacecraft using GNSS, INS, and star tracker
Global Navigation Satellite System (GNSS) can provide an approach for spacecraft autonomous navigation in earth–moon space to make up for the insufficiency of earth-based tracking, telemetry, and control syste...
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Article
Open AccessImproving the underwater navigation performance of an IMU with acoustic long baseline calibration
Underwater acoustic Long-Baseline System (LBL) is an important technique for submarine positioning and navigation. However, the high cost of the seafloor equipment and complex construction of a seafloor networ...
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Article
Open AccessRepeated Omicron exposures override ancestral SARS-CoV-2 immune imprinting
The continuing emergence of SARS-CoV-2 variants highlights the need to update COVID-19 vaccine compositions. However, immune imprinting induced by vaccination based on the ancestral (hereafter referred to as W...
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Article
Open AccessTree and shrub richness modifies subtropical tree productivity by regulating the diversity and community composition of soil bacteria and archaea
Declines in plant biodiversity often have negative consequences for plant community productivity, and it becomes increasingly acknowledged that this may be driven by shifts in soil microbial communities. So fa...
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Article
Open AccessImplicit reward-based motor learning
Binary feedback, providing information solely about task success or failure, can be sufficient to drive motor learning. While binary feedback can induce explicit adjustments in movement strategy, it remains un...
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Article
Open AccessTherapeutic effect of Duhuo Jisheng Decoction add-on Tui-na manipulation on osteoarthritis of knee: a randomized controlled trial
Knee osteoarthritis (KOA) is a common degenerative joint condition that causes disability and pain in the elderly population. The prevalence of KOA among persons aged 63 or above is approximately 30%. Previous...
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Article
Open AccessImprinted SARS-CoV-2 humoral immunity induces convergent Omicron RBD evolution
Continuous evolution of Omicron has led to a rapid and simultaneous emergence of numerous variants that display growth advantages over BA.5 (ref. 1). Despite their divergent evolutionary courses, mutations on the...
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Article
Open AccessAa-Z2 triggers ROS-induced apoptosis of osteosarcoma by targeting PDK-1
Osteosarcoma (OS) is the most frequent cancer derived from bone, and the prognosis of OS is poor. Metabolic alterations have been previously reported to contribute to the development of OS, and arsenic compoun...
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Article
Open AccessConstruction and validation of a prognostic model for osteosarcoma patients based on autophagy-related genes
Osteosarcoma is the most frequent primary bone malignancy with a poor prognosis because of pulmonary metastasis. Autophagy is strongly associated with tumor metastasis, and it is valuable to construct an autop...
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Article
Open AccessCorrection: Dynamics of gut microbiota during pregnancy in women with TPOAb-positive subclinical hypothyroidism: a prospective cohort study
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Article
Open AccessBA.2.12.1, BA.4 and BA.5 escape antibodies elicited by Omicron infection
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron sublineages BA.2.12.1, BA.4 and BA.5 exhibit higher transmissibility than the BA.2 lineage1. The receptor binding and immune-evasion capability...
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Article
Open AccessDynamics of gut microbiota during pregnancy in women with TPOAb-positive subclinical hypothyroidism: a prospective cohort study
Anti-thyroid peroxidase antibody (TPOAb) positivity can contribute to inhibit thyroxine synthesis. Gut microbiota can interact with metabolic or immune diseases. However, dynamics of gut microbiota from the se...
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Article
Open AccessEfficacy and safety of modified **ao-Feng Powder in the treatment of chronic urticaria: protocol of a randomized double-blind placebo-controlled study
Chronic Urticaria (CU), a common skin disorder known as Yin Zhen in Chinese medicine, is characterized by recurrent, pruritic, pink-to-red edematous lesions and wheals on the skin. **ao-Feng Powder (XFP, meani...
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Article
Open AccessBound states at partial dislocation defects in multipole higher-order topological insulators
The bulk-boundary correspondence, which links a bulk topological property of a material to the existence of robust boundary states, is a hallmark of topological insulators. However, in crystalline topological ...
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Article
Open AccessHigh drug-loaded microspheres enabled by controlled in-droplet precipitation promote functional recovery after spinal cord injury
Drug delivery systems with high content of drug can minimize excipients administration, reduce side effects, improve therapeutic efficacy and/or promote patient compliance. However, engineering such systems is...
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Article
Open AccessOmicron escapes the majority of existing SARS-CoV-2 neutralizing antibodies
The SARS-CoV-2 B.1.1.529 (Omicron) variant contains 15 mutations of the receptor-binding domain (RBD). How Omicron evades RBD-targeted neutralizing antibodies requires immediate investigation. Here we use high...
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Chapter and Conference Paper
A Method to Correct the Raw Doppler Observations for GNSS Velocity Determination
In the application of GNSS in the velocity determination, it is often the case that some GNSS receivers give an opposite sign for the raw Doppler observations which do not correspond to the real Doppler shift....
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Article
Open AccessStructures of SARS-CoV-2 B.1.351 neutralizing antibodies provide insights into cocktail design against concerning variants
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Article
Open AccessHumoral immune response to circulating SARS-CoV-2 variants elicited by inactivated and RBD-subunit vaccines
SARS-CoV-2 variants could induce immune escape by mutations on the receptor-binding domain (RBD) and N-terminal domain (NTD). Here we report the humoral immune response to circulating SARS-CoV-2 variants, such...
