-
Article
Open AccessWeyl spin-momentum locking in a chiral topological semimetal
Spin-orbit coupling in noncentrosymmetric crystals leads to spin-momentum locking – a directional relationship between an electron’s spin angular momentum and its linear momentum. Isotropic orthogonal Rashba s...
-
Article
Open AccessDichotomic Role of Low-Concentration EGCG in the Oxaliplatin Sensitivity of Colorectal Cancer Cells
Although epigallocatechin-3-gallate (EGCG) can potentiate chemotherapeutic drugs at high concentrations, its clinical translation is hampered by exceeding possible concentration thresholds. This study proposes...
-
Article
The immunomodulatory effects of metformin in LPS-induced macrophages: an in vitro study
The study aimed to explore the immunomodulatory effects of clinically relevant concentrations of metformin on macrophages during sepsis, which is characterized by an initial hyperinflammatory phase followed by...
-
Article
Tripterine Serves a Dual Role in Palmitate-Induced Pancreatic Beta-Cell Lipotoxicity
Tripterine (TP, also called celastrol), a pentacyclic triterpene extracted from Tripterygium wilfordii, has beneficial effects on multiple diseases, including obesity and diabetes. However, the effects of TP on β...
-
Article
Development and characterization of EST-SSR markers in Rhodomyrtus tomentosa Hassk. based on transcriptome
Rhodomyrtus tomentosa Hassk is a flowering evergreen plant with traditional medicine and ornamental usages. This study aimed to develop a set of EST-SSRs markers for genetic diversity analysis of R. tomentosa. Tr...
-
Article
Fucoxanthin Alleviates Lipopolysaccharide-Induced Inflammation and Immunosuppression in RAW264.7 Macrophages
Fucoxanthin (FX) has been reported to reduce mortality in mouse models of sepsis, but its exact cause remains to be determined. In the present study, we evaluated the immunomodulatory properties of FX in lipop...
-
Article
Basic Fibroblast Growth Factor Blockade Leads to Distinct Cellular Responses in Melanoma B16 Cells
Although bFGF is highly expressed in the melanoma tissues, its specific role in melanoma progression is still not completely clarified. Here, we investigated the consequent cellular responses in melanoma B16 c...
-
Article
Open AccessBound states at partial dislocation defects in multipole higher-order topological insulators
The bulk-boundary correspondence, which links a bulk topological property of a material to the existence of robust boundary states, is a hallmark of topological insulators. However, in crystalline topological ...
-
Article
Two new species of medusae (Cnidaria) from the coastal waters of the northern Beibu Gulf
Medusae in 116 samples collected from the coastal waters of the northern Beibu Gulf during four seasonal oceanographic cruises from October 2017 to August 2018 were analyzed. In total, 34 species were identifi...
-
Article
Open AccessIrreversible electroporation plus allogenic Vγ9Vδ2 T cells enhances antitumor effect for locally advanced pancreatic cancer patients
Immunotherapy has limited efficacy against locally advanced pancreatic cancer (LAPC) due to the presence of an immunosuppressive microenvironment (ISM). Irreversible electroporation (IRE) can not only induce i...
-
Article
Open AccessPhenotypic and genetic spectrum of isolated macrodactyly: somatic mosaicism of PIK3CA and AKT1 oncogenic variants
Isolated macrodactyly is a severe congenital hand anomaly with functional and physiological impact. Known causative genes include PIK3CA, AKT1 and PTEN. The aim of this study is to gain insights into the genetics...
-
Article
Open AccessCost-effectiveness analysis of using the TBX6-associated congenital scoliosis risk score (TACScore) in genetic diagnosis of congenital scoliosis
We previously reported a novel clinically distinguishable subtype of congenital scoliosis (CS), namely, TBX6-associated congenital scoliosis (TACS). We further developed the TBX6-associated CS risk score (TACScor...
-
Article
Open AccessA novel COMP mutation in a Chinese family with multiple epiphyseal dysplasia
Multiple epiphyseal dysplasia (MED) is a skeletal disorder characterized by delayed and irregular ossification of the epiphyses and early-onset osteoarthritis. At least 66% of the reported autosomal dominant M...
-
Article
Bionic optimization design for a CNC turntable based on thermal–mechanical coupling effect
During the machining process, the thermal–mechanical coupling effect of CNC turntable is produced by the action of variable loads and various heat sources. In order to improve the static and dynamic characteri...
-
Article
Design and test of the crank slider mechanism feeding type rubber rotary cutting machine
Aiming at the problems such as low processing efficiency and high labor intensity when the rubber block was processed, a new type of crank slider mechanism feeding style rubber rotary cutting machine was desig...
-
Article
A new pelagic Polyconchoecia **ang, Chen and Du, 2018 (Ostracoda: Myodocopa: Halocyprididae) from the South China Sea
Halocyprid ostracods are appreciable part of ostracods floating through virtually everywhere in marine environment. In this study, we describe a new species of genus Polyconchoecia **ang, Chen and Du, 2018, tribe...
-
Article
Apigenin protects human melanocytes against oxidative damage by activation of the Nrf2 pathway
Vitiligo is a chronic, autoimmune destruction of melanocytes, resulting in progressively expanding depigmented skin patches. Severity of the disorder, which affects approximately 1% of humans, may be mitigated...
-
Article
Open AccessRobust temporal pum** in a magneto-mechanical topological insulator
The transport of energy through 1-dimensional (1D) waveguiding channels can be affected by sub-wavelength disorder, resulting in undesirable localization and backscattering phenomena. However, quantized disord...
-
Article
Thermal–Mechanical Coupling Analysis and Experimental Study on CNC Machine Tool Feed Mechanism
As the CNC machine tool feed mechanism is affected by joint action of heat and load during the working process, thermal–mechanical coupling analysis and experimental research on CNC machine tool feed mechanism...
-
Article
Zooplankton composition and distribution in the Lembeh Strait of North Sulawesi, Indonesia
Based on oceanographic survey data in June 2012 in the Lembeh Strait, the zooplankton ecological characteristics such as species composition, individual abundance, dominant species and distribution were analyz...
