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Article
A novel human single-domain antibody-drug conjugate targeting CEACAM5 exhibits potent in vitro and in vivo antitumor activity
Leveraging the specificity of antibody to deliver cytotoxic agent into tumor, antibody-drug conjugates (ADCs) have become one of the hotspots in the development of anticancer therapies. Although significant pr...
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Article
Open AccessA novel and effective approach to generate germline-like monoclonal antibodies by integration of phage and mammalian cell display platforms
Phage display technology allows for rapid selection of antibodies from the large repertoire of human antibody fragments displayed on phages. However, antibody fragments should be converted to IgG for biologica...
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Article
Molecular modeling and dynamics simulation of a histidine-tagged cytochrome b 5
Although an affinity tag such as six consecutive histidines, (His)6-tag, has been widely used to obtain high quantity of recombinant proteins, little is known about its influences on heme proteins for lack of str...
