11 Result(s)
within
Tian **u Wen
Cell Biology
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Article
Open AccessRUVBL1 ubiquitination by DTL promotes RUVBL1/2-β-catenin-mediated transcriptional regulation of NHEJ pathway and enhances radiation resistance in breast cancer
Radiotherapy effectiveness in breast cancer is limited by radioresistance. Nevertheless, the mechanisms behind radioresistance are not yet fully understood. RUVBL1 and RUVBL2, referred to as RUVBL1/2, are cruc...
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Article
Open AccessTherapeutic potential of MSCs and MSC-derived extracellular vesicles in immune thrombocytopenia
Immune thrombocytopenia (ITP) is an acquired autoimmune disease involving a variety of immune cells and factors. Despite being a benign disease, it is still considered incurable due to its complex pathogenesis...
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Article
AMPK Ameliorates Tau Acetylation and Memory Impairment Through Sirt1
Alzheimer’s disease (AD) is the most common neurodegenerative disease, but its underlying mechanism is still unclear and the identities of drugs for AD also lack. Tau acetylation has become potentially importa...
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Article
Upregulation of AMPK Ameliorates Alzheimer’s Disease-Like Tau Pathology and Memory Impairment
The studies have shown that 5′-adenosine monophosphate (AMP)-activated protein kinase (AMPK) is involved in Alzheimer’s disease (AD) pathology, but the effects of AMPK on AD-like Tau abnormal phosphorylation a...
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Article
Open AccessTwo functional variants at 6p21.1 were associated with lean mass
Low lean body mass is the most important predictor of sarcopenia with strong genetic background. The aim of this study was to uncover genetic factors underlying lean mass development.
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Article
Long Noncoding RNA Analyses for Osteoporosis Risk in Caucasian Women
Osteoporosis is a prevalent bone metabolic disease characterized by bone fragility. As a key pathophysiological mechanism, the disease is caused by excessive bone resorption (by osteoclasts) over bone formatio...
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Transcriptomic Data Identified Key Transcription Factors for Osteoporosis in Caucasian Women
Osteoporosis is a prevalent bone metabolic disease, mainly caused by excessive bone resorption (by osteoclasts) over bone formation (by osteoblasts). Identifying the key transcription factors and understanding...
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Open AccessGrowth arrest specific gene 2 in tilapia (Oreochromis niloticus): molecular characterization and functional analysis under low-temperature stress
Growth arrest specific 2 (gas2) gene is a component of the microfilament system that plays a major role in the cell cycle, regulation of microfilaments, and cell morphology during apoptotic processes. However, li...
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Article
PPARGC1B gene is associated with Kashin-Beck disease in Han Chinese
Kashin-Beck disease (KBD) is a chronic osteochondropathy. The genetic basis of KBD remains elusive now. To investigate the relationship between PPARGC1B gene polymorphism and KBD, we conducted a two-stage associa...
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Article
Exome sequencing identified FGF12 as a novel candidate gene for Kashin-Beck disease
The objective of this study was to identify novel causal genes involved in the pathogenesis of Kashin-Beck disease (KBD). A representative grade III KBD sib pair with serious skeletal growth and development fa...
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Article
Regeneration of Prunus salicina Lindl (Japanese plum) from hypocotyls of mature seeds
Plant regeneration of Prunus salicina (Japanese plum) using mature seeds was studied and evaluated. Shoots were effectively induced from hypocotyl slices of mature seeds on media containin...
