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Article
Open AccessIsatuximab, lenalidomide, dexamethasone and bortezomib in transplant-ineligible multiple myeloma: the randomized phase 3 BENEFIT trial
CD38-targeting immunotherapy is approved in combination with lenalidomide and dexamethasone in patients with newly diagnosed multiple myeloma (NDMM) that are transplant ineligible (TI) and is considered the be...
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Article
Open AccessSex differences in DNA methylation across gestation: a large scale, cross-cohort, multi-tissue analysis
Biological sex is a key variable influencing many physiological systems. Disease prevalence as well as treatment success can be modified by sex. Differences emerge already early in life and include pregnancy c...
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Article
Open AccessA Sustainable Translational Sheep Model for Planned Cesarean Delivery of Contraction-Free Ewes
We evaluated whether the sheep constitutes a useful translational model to evaluate anatomical and surgical aspects of cesarean delivery (CD) from a human medical perspective with the aim of both maternal and ...
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Article
Questioning the fetal microbiome illustrates pitfalls of low-biomass microbial studies
Whether the human fetus and the prenatal intrauterine environment (amniotic fluid and placenta) are stably colonized by microbial communities in a healthy pregnancy remains a subject of debate. Here we evaluat...
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Placenta-Related Hemorrhage: Pathophysiology, Diagnostics, Management
The placenta is the interface between mother and child, and has a decisive influence on the development of the unborn child and the health of the mother. All too often, no special attention is paid to the role...
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Article
Open AccessA multiparametric niche-like drug screening platform in acute myeloid leukemia
Functional precision medicine in AML often relies on short-term in vitro drug sensitivity screening (DSS) of primary patient cells in standard culture conditions. We designed a niche-like DSS assay combining p...
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Article
Cystine uptake inhibition potentiates front-line therapies in acute myeloid leukemia
By querying metabolic pathways associated with leukemic stemness and survival in multiple AML datasets, we nominated SLC7A11 encoding the xCT cystine importer as a putative AML dependency. Genetic and chemical in...
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Article
Open AccessResponse to Letter to the editor on: “Never too late? Quadruplets at the age of 65 years”
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Article
Open AccessPlacenta Percreta Presents with Neoangiogenesis of Arteries with Von Willebrand Factor-Negative Endothelium
In placenta percreta cases, large vessels are present on the precrete surface area. As these vessels are not found in normal placentation, we examined their histological structure for features that might expla...
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Article
Open AccessReliability of a novel approach for reference-based cell type estimation in human placental DNA methylation studies
The placenta is a central organ during early development, influencing trajectories of health and disease. DNA methylation (DNAm) studies of human placenta improve our understanding of how its function relates ...
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Article
Open AccessReply to: “Hysterectomy versus continuing conservative management: which is better for disseminated intravascular coagulation?”; Shinya Matsuzaki, MD, PhD, Yoshikazu Nagase, MD, Masayuki Endo, MD, PhD, Tadashi Kimura, MD, PhD
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Article
Open AccessNever too late? Quadruplets at the age of 65 years
We discuss the challenges of multiple pregnancy at very advanced reproductive age.
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Article
Open AccessBetamethasone administration during pregnancy is associated with placental epigenetic changes with implications for inflammation
Glucocorticoids (GCs) play a pivotal role in fetal programming. Antenatal treatment with synthetic GCs (sGCs) in individuals in danger of preterm labor is common practice. Adverse short- and long-term effects ...
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Article
Fetal meconium does not have a detectable microbiota before birth
Microbial colonization of the human intestine impacts host metabolism and immunity; however, exactly when colonization occurs is unclear. Although many studies have reported bacterial DNA in first-pass meconiu...
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Article
Open AccessMaternal Serum VEGF Predicts Abnormally Invasive Placenta Better than NT-proBNP: a Multicenter Case-Control Study
The aim of this study was to test if maternal serum vascular endothelial growth factor (VEGF) or N-terminal pro B-type natriuretic peptide (NT-proBNP) predicts abnormally invasive placenta (AIP) better. Second...
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Intrapartum Translabial Ultrasound (ITU) to Assess Birth Progress
For many years, diagnostic ultrasound has had a place in the labor ward. Recently, it has also been applied to assess birth progress. Initially, the position of the fetal spine and occiput was assessed by tran...
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Article
Adult T-cell acute lymphoblastic leukemias with IL7R pathway mutations are slow-responders who do not benefit from allogeneic stem-cell transplantation
The prognostic value of IL7-receptor pathway (IL7Rp) mutations in T-cell acute lymphoblastic leukemia (T-ALL) remains unclear. We performed a comprehensive study of 200 adult patients with T-ALL included in th...
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Autologous haematopoietic stem cell transplantation (AHSCT) in autoimmune disease adult patients in France: analysis of the long-term outcome from the French Society for Bone Marrow Transplantation and Cellular Therapy (SFGM-TC)
The use of autologous haematopoietic stem cell transplantation (AHSCT) in autoimmune disease (AD) patients has increased progressively worldwide. We retrospectively analysed the long-term outcome of AHSCT for ...
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Plazentabedingte Blutungen: Pathophysiologie, Diagnostik, Management
Die Plazenta im Spannungsfeld zwischen Mutter und Kind nimmt entscheidend Einfluss auf die Entwicklung des ungeborenen Kindes und den Gesundheitszustand der Mutter. Allzu oft wird der Rolle der Plazenta keine ...
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Article
Open AccessMutation allele burden remains unchanged in chronic myelomonocytic leukaemia responding to hypomethylating agents
The cytidine analogues azacytidine and 5-aza-2’-deoxycytidine (decitabine) are commonly used to treat myelodysplastic syndromes, with or without a myeloproliferative component. It remains unclear whether the r...
