32 Result(s)
within
Thomas M. Gress
English
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Article
Open AccessA systems biology approach to define mechanisms, phenotypes, and drivers in PanNETs with a personalized perspective
Pancreatic neuroendocrine tumors (PanNETs) are a rare tumor entity with largely unpredictable progression and increasing incidence in developed countries. Molecular pathways involved in PanNETs development are...
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Article
Open AccessRamucirumab in combination with dacarbazine in patients with progressive well-differentiated metastatic pancreatic neuroendocrine tumors (RamuNET): study protocol for a multicenter single-arm trial
Cytotoxic chemotherapy combinations and targeted agents represent established treatment concepts in advanced pancreatic neuroendocrine tumors (PNETs). However, response rates, side effects and outcome data str...
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Article
Open AccessMicrobial short-chain fatty acids modulate CD8+ T cell responses and improve adoptive immunotherapy for cancer
Emerging data demonstrate that the activity of immune cells can be modulated by microbial molecules. Here, we show that the short-chain fatty acids (SCFAs) pentanoate and butyrate enhance the anti-tumor activi...
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Article
Open AccessThe POLD1R689W variant increases the sensitivity of colorectal cancer cells to ATR and CHK1 inhibitors
Inhibition of the kinase ATR, a central regulator of the DNA damage response, eliminates subsets of cancer cells in certain tumors. As previously shown, this is at least partly attributable to synthetic lethal...
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Article
Long-term outcome of surgical resection in patients with gastroenteropancreatic neuroendocrine neoplasia: results from a German nation-wide multi-centric registry
Neuroendocrine neoplasia (NEN) are rare and heterogenous tumours. Few data exist on the impact of surgical therapy.
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Article
Open AccessAuthor Correction: TGF-β induces miR-100 and miR-125b but blocks let-7a through LIN28B controlling PDAC progression
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Open AccessBrain metastases in patients with neuroendocrine neoplasms: risk factors and outcome
Brain metastases (BM) are rarely reported in patients with neuroendocrine carcinoma (NEC) of non-lung origin and neuroendocrine tumors (NET) of the gastroenteropancreatic (GEP) or bronchopulmonary system. Howe...
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Article
DYRK1B regulates Hedgehog-induced microtubule acetylation
The posttranslational modification (PTM) of tubulin subunits is important for the physiological functions of the microtubule (MT) cytoskeleton. Although major advances have been made in the identification of e...
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Article
Open AccessTGF-β induces miR-100 and miR-125b but blocks let-7a through LIN28B controlling PDAC progression
TGF-β/Activin induces epithelial-to-mesenchymal transition and stemness in pancreatic ductal adenocarcinoma (PDAC). However, the microRNAs (miRNAs) regulated during this response have remained yet undetermined...
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Article
Smoking and bone mineral density: comprehensive analyses of the third National Health and Nutrition Examination Survey (NHANES III)
Some questions remain on the relationship between smoking and bone health. Detailed analyses of the relationship between smoking and BMD are presented, essentially ruling out non-linear associations as an expl...
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Article
Open AccessDocOx (AIO-PK0106): a phase II trial of docetaxel and oxaliplatin as a second line systemic therapy in patients with advanced pancreatic ductal adenocarcinoma
The current study was conducted to examine the activity of a docetaxel/oxaliplatin (DocOx) combination as second line treatment for advanced pancreatic ductal adenocarcinoma (Trial registration: NCT00690300. R...
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Article
Open AccessParaneoplastic brainstem encephalitis in a patient with exceptionally long course of a metastasized neuroendocrine rectum neoplasm
Paraneoplastic neurological syndromes (PNS) have frequently been described in patients with lung or breast cancer. However, some reports also described a correlation to carcinoid tumors, probably triggered via...
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Article
Familial pancreatic cancer—current knowledge
Familial pancreatic cancer (FPC) is a rare, hereditary tumour syndrome. High morbidity and mortality is associated with development of pancreatic cancer in these high-risk individuals and, as outlined in this ...
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Article
Differentiation of multiple types of pancreatico-biliary tumors by molecular analysis of clinical specimens
Timely and accurate diagnosis of pancreatic ductal adenocarcinoma (PDAC) is critical in order to provide adequate treatment to patients. However, the clinical signs and symptoms of PDAC are shared by several t...
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Article
Open AccessSignificantly improved precision of cell migration analysis in time-lapse video microscopy through use of a fully automated tracking system
Cell motility is a critical parameter in many physiological as well as pathophysiological processes. In time-lapse video microscopy, manual cell tracking remains the most common method of analyzing migratory b...
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Reference Work Entry In depth
Principles and Applications of Microarray Gene Expression in Pancreatic Cancer
Like most other malignancies, pancreatic cancer is a polygenic disease arising from the accumulation of multiple genetic and epigenetic defects in the affected cells. DNA arrays offer the possibility to monito...
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Reference Work Entry In depth
Molecular Pathology of Ampullary, Intra-Pancreatic Bile Duct and Duodenal Cancers
Periampullary cancers include carcinomas of the pancreatic head, ampullary cancers at the papilla of Vater, duodenal cancers and distal bile duct cancers. Due to their anatomical location close to the orifice ...
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Article
Open AccessVennMaster: Area-proportional Euler diagrams for functional GO analysis of microarrays
Microarray experiments generate vast amounts of data. The functional context of differentially expressed genes can be assessed by querying the Gene Ontology (GO) database via GoMiner. Directed acyclic graph re...
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Article
Chymotrypsin C (CTRC) variants that diminish activity or secretion are associated with chronic pancreatitis
Chronic pancreatitis is a persistent inflammatory disease of the pancreas, in which the digestive protease trypsin has a fundamental pathogenetic role. Here we have analyzed the gene encoding the trypsin-degra...
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Article
Open AccessMatrix-comparative genomic hybridization from multicenter formalin-fixed paraffin-embedded colorectal cancer tissue blocks
The identification of genomic signatures of colorectal cancer for risk stratification requires the study of large series of cancer patients with an extensive clinical follow-up. Multicentric clinical studies r...
