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Article
Major Postoperative Complications Limit Adjuvant Therapy Administration in Patients Undergoing Pancreatoduodenectomy for Distal Cholangiocarcinoma or Pancreatic Ductal Adenocarcinoma
Guidelines for perioperative systemic therapy administration in patients undergoing pancreatoduodenectomy for pancreatic adenocarcinoma (PDAC) and distal cholangiocarcinoma (dCCA) are evolving. Decisions regar...
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Article
Hypoxia Inducible Factor-1α binds and activates γ-secretase for Aβ production under hypoxia and cerebral hypoperfusion
Hypoxic-ischemic injury has been linked with increased risk for develo** Alzheimer’s disease (AD). The underlying mechanism of this association is poorly understood. Here, we report distinct roles for hypoxi...
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Article
Open AccessNanocrown electrodes for parallel and robust intracellular recording of cardiomyocytes
Drug-induced cardiotoxicity arises primarily when a compound alters the electrophysiological properties of cardiomyocytes. Features of intracellular action potentials (iAPs) are powerful biomarkers that predic...
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Article
Open AccessIMI2-PainCare-BioPain-RCT1: study protocol for a randomized, double-blind, placebo-controlled, crossover, multi-center trial in healthy subjects to investigate the effects of lacosamide, pregabalin, and tapentadol on biomarkers of pain processing observed by peripheral nerve excitability testing (NET)
Few new drugs have been developed for chronic pain. Drug development is challenged by uncertainty about whether the drug engages the human target sufficiently to have a meaningful pharmacodynamic effect. IMI2-...
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Article
The innate immunity protein IFITM3 modulates γ-secretase in Alzheimer’s disease
Innate immunity is associated with Alzheimer’s disease1, but the influence of immune activation on the production of amyloid-β is unknown2,3. Here we identify interferon-induced transmembrane protein 3 (IFITM3) a...
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Article
Open AccessAuthor Correction: Hybrid PET/MRI enables high-spatial resolution, quantitative imaging of amyloid plaques in an Alzheimer’s disease mouse model
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Open AccessHybrid PET/MRI enables high-spatial resolution, quantitative imaging of amyloid plaques in an Alzheimer’s disease mouse model
The emergence of PET probes for amyloid plaques and neurofibrillary tangles, hallmarks of Alzheimer disease (AD), enables monitoring of pathology in AD mouse models. However, small-animal PET imaging is limite...
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Article
Open AccessDefining responders to therapies by a statistical modeling approach applied to randomized clinical trial data
Personalized medicine is the tailoring of treatment to the individual characteristics of patients. Once a treatment has been tested in a clinical trial and its effect overall quantified, it would be of great v...
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Chapter and Conference Paper
SingleGAN: Image-to-Image Translation by a Single-Generator Network Using Multiple Generative Adversarial Learning
Image translation is a burgeoning field in computer vision where the goal is to learn the map** between an input image and an output image. However, most recent methods require multiple generators for modeli...
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Chapter and Conference Paper
Continual Business Transformation Technology
Enterprises always have to pursue for profitability while maintaining long term competitive advantages. Today, this task becomes more challenging due to globalization and dynamic changing business environment....
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Article
Short-term outcome of critically ill patients with severe acute respiratory syndrome
To document the outcome and determine prognostic factors for patients with severe acute respiratory syndrome who require admission to an intensive care unit.
