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  1. No Access

    Article

    In vivo efficacy of mutant IDH1 inhibitor HMS-101 and structural resolution of distinct binding site

    Mutations in isocitrate dehydrogenase 1 (IDH1) are found in 6% of AML patients. Mutant IDH produces R-2-hydroxyglutarate (R-2HG), which induces histone- and DNA-hypermethylation through the inhibition of epigenet...

    Anuhar Chaturvedi, Ramya Goparaju, Charu Gupta, Julia Weder, Thomas Klünemann… in Leukemia (2020)

  2. Article

    Open Access

    Position 123 of halohydrin dehalogenase HheG plays an important role in stability, activity, and enantioselectivity

    HheG from Ilumatobacter coccineus is a halohydrin dehalogenase with synthetically useful activity in the ring opening of cyclic epoxides with various small anionic nucleophiles. This enzyme provides access to chi...

    Jennifer Solarczek, Thomas Klünemann, Felix Brandt, Patrick Schrepfer… in Scientific Reports (2019)

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