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Article
An attention-based bidirectional LSTM-CNN architecture for the early prediction of sepsis
Sepsis is a severe and expensive medical emergency that requires prompt identification in order to improve patient mortality. The objective of our research is to develop an attention-based bidirectional LSTM-C...
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Article
Open AccessContinuous monitoring of physiological data using the patient vital status fusion score in septic critical care patients
Accurate and standardized methods for assessing the vital status of patients are crucial for patient care and scientific research. This study introduces the Patient Vital Status (PVS), which quantifies and con...
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Chapter and Conference Paper
Algorithmic Fairness in Healthcare Data with Weighted Loss and Adversarial Learning
Fairness in terms of various sensitive or protected attributes such as race, gender, age group, etc. has been a subject of great importance in the healthcare domain. Group fairness is considered as one of the ...
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Article
Open AccessAwareness and diagnosis for intra-abdominal hypertension (IAH) and abdominal compartment syndrome (ACS) in neonatal (NICU) and pediatric intensive care units (PICU) – a follow-up multicenter survey
Constantly elevated intra-abdominal pressure (IAH) can lead to abdominal compartment syndrome (ACS), which is associated with organ dysfunction and even multiorgan failure. Our 2010 survey revealed an inconsis...
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Article
Open AccessDBS emergency surgery for treatment of dystonic storm associated with rhabdomyolysis and acute colitis in DYT-GNAO1
Patients with variants in the GNAO1 gene may present with life-threatening dystonic storm. There is little experience using pallidal deep brain stimulation (DBS) as an emergency treatment in such cases.
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Article
Open AccessClinical evaluation of an interoperable clinical decision-support system for the detection of systemic inflammatory response syndrome in critically ill children
Systemic inflammatory response syndrome (SIRS) is defined as a non-specific inflammatory process in the absence of infection. SIRS increases susceptibility for organ dysfunction, and frequently affects the cli...
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Article
Open AccessDevelopment and validation of a diagnostic model for early differentiation of sepsis and non-infectious SIRS in critically ill children - a data-driven approach using machine-learning algorithms
Since early antimicrobial therapy is mandatory in septic patients, immediate diagnosis and distinction from non-infectious SIRS is essential but hampered by the similarity of symptoms between both entities. We...
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Article
Open AccessDevelopment and virucidal activity of a novel alcohol-based hand disinfectant supplemented with urea and citric acid
Hand disinfectants are important for the prevention of virus transmission in the health care system and environment. The development of broad antiviral spectrum hand disinfectants with activity against envelop...
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Article
Dialysis-dependent acute kidney injury in children with end-stage liver disease: prevalence, dialysis modalities and outcome
Acute kidney injury (AKI) is a major complication in children with hepatic failure which leads to increased morbidity and mortality. The aim of this study was to provide paediatric data on the prevalence of di...
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Article
Open AccessIn-line Filtration Decreases Systemic Inflammatory Response Syndrome, Renal and Hematologic Dysfunction in Pediatric Cardiac Intensive Care Patients
Cardiac surgery with cardiopulmonary bypass (CPB) frequently leads to systemic inflammatory response syndrome (SIRS) with concomitant organ malfunction. Infused particles may exacerbate inflammatory syndromes ...
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Article
Open AccessIn-line filtration minimizes organ dysfunction: New aspects from a prospective, randomized, controlled trial
Infused particles induce thrombogenesis, impair microcirculation and modulate immune response. We have previously shown in critically ill children, that particle-retentive in-line filtration reduced the overal...
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Article
Open AccessIn-line filtration reduces severe complications and length of stay on pediatric intensive care unit: a prospective, randomized, controlled trial
Particulate contamination due to infusion therapy carries a potential health risk for intensive care patients.
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Article
Open AccessAnalysis of particulate contaminations of infusion solutions in a pediatric intensive care unit
To examine the physical properties and chemical composition of particles captured by in-line microfilters in critically ill children, and to investigate the inflammatory and cytotoxic effects of particles on e...
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Article
Drosseldichtungen für Kurbelwellenlager
Unterschiedliche Wärmeausdehnungskoeffizienten von Motorblöcken aus Leichtmetall und Kurbelwellen aus Stahl verursachen bei hohen Betriebstemperaturen große Lagerspalte zwischen Kurbelwelle und Hauptlagerschal...
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Article
Throttle seals for crankshaft bearings
At high operating temperatures, differences in the coefficients of thermal expansion for light metal engine blocks and steel crankshafts cause large bearing gaps to open up between the crankshaft and the main ...
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Article
DORNRÖSCHEN-LIKE, an AP2 gene, is necessary for stamen emergence in Arabidopsis
To identify novel genes in petal and stamen development, a genetic screen was carried out for enhancers of the unusual B class mutant pistillata-5 (pi-5). In pi-5 flowers, second whorl organs develop as sepals ra...
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Article
Human protein C concentrate in the treatment of hemolytic uremic syndrome
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Article
Defining subdomains of the K domain important for protein–protein interactions of plant MADS proteins
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Article
Plant development going MADS
It has been known for a decade that the plant MADS genesare important regulators of meristem and floral organ identity. The MADS family in Arabidopsis consists of more than 80 members and, until recently, the fun...
