15 Result(s)
within
Thomas E. Spencer
Life Sciences
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Article
Open AccessUterine lumen fluid is metabolically semi-autonomous
Uterine lumen fluid (ULF) is central to successful pregnancy establishment and maintenance, and impacts offspring wellbeing into adulthood. The current dogma is that ULF composition is primarily governed by en...
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Chapter
Mammalian Placentation: A Tribute to E.C. Amoroso’s Contributions to Placenta Development
Establishment of viviparity in mammals evolved through not only the long-term retainment of the fetus within the maternal uterus but differentiation and expansion of cell layers to form functional membranes to...
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Chapter
Implantation and Placentation in Ruminants
In comparison to many other mammalian species, ruminant ungulates have a unique form of placentation. Ruminants initially display an epitheliochorial type of placentation; however, during the period of placent...
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Article
Open AccessIdentification of loci associated with conception rate in primiparous Holstein cows
Subfertility is a major issue facing the dairy industry as the average US Holstein cow conception rate (CCR) is approximately 35%. The genetics underlying the physiological processes responsible for CCR, the p...
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Article
Open AccessValidation of 46 loci associated with female fertility traits in cattle
Subfertility is one challenge facing the dairy industry as the average Holstein heifer conception rate (HCR), the proportion of heifers that conceive and maintain a pregnancy per breeding, is estimated at 55–6...
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Article
Open AccessConceptus elongation in ruminants: roles of progesterone, prostaglandin, interferon tau and cortisol
The majority of pregnancy loss in ruminants occurs during the first three weeks after conception, particularly during the period of conceptus elongation that occurs prior to pregnancy recognition and implantat...
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Article
Open AccessAlterations in expression of endometrial genes coding for proteins secreted into the uterine lumen during conceptus elongation in cattle
We hypothesized that genes that are up-regulated in the uterine endometrium at the initiation of conceptus elongation in cattle, and that encode for secreted proteins, contribute to the composition of the uter...
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Chapter
The Evolutionary Interplay Between Exogenous and Endogenous Sheep Betaretroviruses
Sheep betaretroviruses represent an interesting model to study the complex evolutionary interplay between host and pathogen in natural settings. In infected sheep, the exogenous and pathogenic Jaagsiekte shee...
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Article
Proline and hydroxyproline metabolism: implications for animal and human nutrition
Proline plays important roles in protein synthesis and structure, metabolism (particularly the synthesis of arginine, polyamines, and glutamate via pyrroline-5-carboxylate), and nutrition, as well as wound hea...
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Article
Beneficial effects of l-arginine on reducing obesity: potential mechanisms and important implications for human health
Over the past 20 years, growing interest in the biochemistry, nutrition, and pharmacology of l-arginine has led to extensive studies to explore its nutritional and therapeutic roles in treating and preventing hum...
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Article
Amino acids and gaseous signaling
Gases, such as nitric oxide (NO), carbon monoxide (CO), hydrogen sulfide (H2S), and sulfur dioxide (SO2) are known toxic pollutants in the air. However, they are now recognized as important signaling molecules sy...
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Article
High fat feeding and dietary l-arginine supplementation differentially regulate gene expression in rat white adipose tissue
Dietary l-arginine (Arg) supplementation reduces white-fat gain in diet-induced obese rats but the underlying mechanisms are unknown. This study tested the hypothesis that Arg treatment affects expression of gene...
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Article
Arginine metabolism and nutrition in growth, health and disease
l-Arginine (Arg) is synthesised from glutamine, glutamate, and proline via the intestinal-renal axis in humans and most other mammals (including pigs, sheep and rats). Arg degradation occ...
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Chapter
Uterine Glands
This chapter focuses on the comparative development and mechanisms regulating branching morphogenesis of endometrial glands in the mammalian uterus. All uteri contain endometrial glands that secrete substances...
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Article
Isolation, immortalization, and initial characterization of uterine cell lines: An in vitro model system for the procine uterus
The aim of this study was to develop immortalized cell lines from porcine uterus. Endometrial cells including luminal epithelium (LE), glandular epithelium (GE), stroma (ST), and myometrium (MYO) were enzymati...
