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Article
Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass
Genetic1,2,3,4,5,6,7,8 and pharmacological6,9,10,11,12 studies have defined a role for the melanocortin-4 receptor (Mc4r) in the regulation of energy homeostasis. The physiological function of Mc3r, a melanocorti...
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Article
Identification of receptors for neuromedin U and its role in feeding
Neuromedin U (NMU) is a neuropeptide with potent activity on smooth muscle which was isolated first from porcine spinal cord and later from other species1,2,3,4,5,6,7,8. It is widely distributed in the gut and ce...
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Article
Role of the melanocortin-4 receptor in metabolic rate and food intake in mice
We evaluated the role of the melanocortin-4 receptor (MC-4R) in the control of metabolic rate and food intake in mice. Intraperitoneal administration of the non-selective MC-R agonist melanotan II (MT-II; a cy...