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Article
Open AccessCOVID-19 induces more pronounced extracellular matrix deposition than other causes of ARDS
Lung fibrosis is a major concern in severe COVID-19 patients undergoing mechanical ventilation (MV). Lung fibrosis frequency in post-COVID syndrome is highly variable and even if the risk is proportionally sma...
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Article
Open AccessBronchial eosinophils, neutrophils, and CD8 + T cells influence asthma control and lung function in schoolchildren and adolescents with severe treatment-resistant asthma
Studies in adult severe treatment-resistant asthma (STRA) have demonstrated heterogeneous pathophysiology. Studies in the pediatric age group are still scarce, and few include bronchial tissue analysis.
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Article
Open AccessPostmortem brain 7T MRI with minimally invasive pathological correlation in deceased COVID-19 subjects
Brain abnormalities are a concern in COVID-19, so we used minimally invasive autopsy (MIA) to investigate it, consisting of brain 7T MR and CT images and tissue sampling via transethmoidal route with at least ...
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Article
Open AccessQuantification of airborne SARS-CoV-2 genomic particles in different hospital settings
We quantified the presence of SARS-CoV-2 RNA in the air of different hospital settings and the autopsy room of the largest medical centre in Sao Paulo, Brazil. Real-time reverse-transcription PCR was used to d...
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Article
Open AccessA single-centre, retrospective study of the incidence of invasive fungal infections during 85 years of autopsy service in Brazil
Autopsy continues to play an essential role in monitoring opportunistic fungal infections. However, few studies have analysed the historical trends of fungal infections in autopsies. Here, we analyse available...
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Article
Ultrasound assessment of pulmonary fibroproliferative changes in severe COVID-19: a quantitative correlation study with histopathological findings
This study was designed to evaluate the usefulness of lung ultrasound (LUS) imaging to characterize the progression and severity of lung damage in cases of COVID-19.
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Article
Open AccessTracking the time course of pathological patterns of lung injury in severe COVID-19
Pulmonary involvement in COVID-19 is characterized pathologically by diffuse alveolar damage (DAD) and thrombosis, leading to the clinical picture of Acute Respiratory Distress Syndrome. The direct action of S...
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Article
Open AccessCorrection to: Structural alterations and markers of endothelial activation in pulmonary and bronchial arteries in fatal asthma
An amendment to this paper has been published and can be accessed via the original article.
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Article
Open AccessNrf2 positively regulates autophagy antioxidant response in human bronchial epithelial cells exposed to diesel exhaust particles
Diesel exhaust particles (DEP) are known to generate reactive oxygen species in the respiratory system, triggering cells to activate antioxidant defence mechanisms, such as Keap1-Nrf2 signalling and autophagy....
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Article
Open AccessStructural alterations and markers of endothelial activation in pulmonary and bronchial arteries in fatal asthma
There is interest in better understanding vessel pathology in asthma, given the findings of loss of peripheral vasculature associated with disease severity by imaging and altered markers of endothelial activat...
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Article
Open AccessSevere pulmonary disease in an adult primary ciliary dyskinesia population in Brazil
Primary Ciliary Dyskinesia (PCD) is underdiagnosed in Brazil. We enrolled patients from an adult service of Bronchiectasis over a two-year period in a cross-sectional study. The inclusion criteria were lateral...
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Article
Open AccessThe Th17/Treg Cytokine Imbalance in Chronic Obstructive Pulmonary Disease Exacerbation in an Animal Model of Cigarette Smoke Exposure and Lipopolysaccharide Challenge Association
We proposed an experimental model to verify the Th17/Treg cytokine imbalance in COPD exacerbation. Forty C57BL/6 mice were exposed to room air or cigarette smoke (CS) (12 ± 1 cigarettes, twice a day, 30 min/ex...
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Article
Open AccessPulmonary interstitial emphysema in fatal asthma: case report and histopathological review
Mortality related to asthma has decreased worldwide since the introduction of inhaled corticosteroid therapy in the past decades. However, there are still some asthma fatalities identified mainly in population...
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Article
Open AccessA Potent Tartrate Resistant Acid Phosphatase Inhibitor to Study the Function of TRAP in Alveolar Macrophages
The enzyme tartrate resistant acid phosphatase (TRAP, two isoforms 5a and 5b) is highly expressed in alveolar macrophages, but its function there is unclear and potent selective inhibitors of TRAP are required...
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Article
Open AccessAirway and parenchyma immune cells in influenza A(H1N1)pdm09 viral and non-viral diffuse alveolar damage
Diffuse alveolar damage (DAD), which is the histological surrogate for acute respiratory distress syndrome (ARDS), has a multifactorial aetiology. Therefore it is possible that the immunopathology differs amon...
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Article
Open AccessOld dilemma: asthma with irreversible airway obstruction or COPD
Older asthmatic patients may develop fixed airway obstruction and clinical signs of chronic obstructive pulmonary disease (COPD). We investigated the added value of pathological evaluation of bronchial biopsie...
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Article
Open AccessChronic exposure of diesel exhaust particles induces alveolar enlargement in mice
Diesel exhaust particles (DEPs) are deposited into the respiratory tract and are thought to be a risk factor for the development of diseases of the respiratory system. In healthy individuals, the timing and me...
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Article
Open AccessRegulation of lung oxidative damage by endogenous superoxide dismutase in sepsis
The purpose of this research is to study the relationship between superoxide dismutase (SOD) and lung redox state in an animal model of sepsis.
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Article
Open AccessBPIFB1 (LPLUNC1) is upregulated in cystic fibrosis lung disease
Although the biology the PLUNC (recently renamed BPI fold, BPIF) family of secreted proteins is poorly understood, multiple array based studies have suggested that some are differentially expressed in lung dis...
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Article
Open AccessSmall airway remodeling in acute respiratory distress syndrome: a study in autopsy lung tissue
Airway dysfunction in patients with the Acute Respiratory Distress Syndrome (ARDS) is evidenced by expiratory flow limitation and dynamic hyperinflation. These functional alterations have been attributed to cl...
