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Article
Open AccessCOVID-19 induces more pronounced extracellular matrix deposition than other causes of ARDS
Lung fibrosis is a major concern in severe COVID-19 patients undergoing mechanical ventilation (MV). Lung fibrosis frequency in post-COVID syndrome is highly variable and even if the risk is proportionally sma...
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Article
Open AccessBronchial eosinophils, neutrophils, and CD8 + T cells influence asthma control and lung function in schoolchildren and adolescents with severe treatment-resistant asthma
Studies in adult severe treatment-resistant asthma (STRA) have demonstrated heterogeneous pathophysiology. Studies in the pediatric age group are still scarce, and few include bronchial tissue analysis.
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Article
Assessing the impact of urban environment and green infrastructure on mental health: results from the São Paulo Megacity Mental Health Survey
Different land cover types in cities, including green areas, have impacts on mental health. Few studies, however, have been conducted in megacities in low-/middle-income countries, which have extremely complex...
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Article
Open AccessPostmortem brain 7T MRI with minimally invasive pathological correlation in deceased COVID-19 subjects
Brain abnormalities are a concern in COVID-19, so we used minimally invasive autopsy (MIA) to investigate it, consisting of brain 7T MR and CT images and tissue sampling via transethmoidal route with at least ...
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Article
Open AccessQuantification of airborne SARS-CoV-2 genomic particles in different hospital settings
We quantified the presence of SARS-CoV-2 RNA in the air of different hospital settings and the autopsy room of the largest medical centre in Sao Paulo, Brazil. Real-time reverse-transcription PCR was used to d...
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Article
Open AccessA single-centre, retrospective study of the incidence of invasive fungal infections during 85 years of autopsy service in Brazil
Autopsy continues to play an essential role in monitoring opportunistic fungal infections. However, few studies have analysed the historical trends of fungal infections in autopsies. Here, we analyse available...
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Article
Ultrasound assessment of pulmonary fibroproliferative changes in severe COVID-19: a quantitative correlation study with histopathological findings
This study was designed to evaluate the usefulness of lung ultrasound (LUS) imaging to characterize the progression and severity of lung damage in cases of COVID-19.
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Article
Building knowledge in urban agriculture: the challenges of local food production in São Paulo and Melbourne
Urban environments face multiple burdens and significant challenges related to food safety and sustainable agriculture. Urban agriculture remains fragmented and incipient in many cities worldwide. In their eff...
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Article
Open AccessTracking the time course of pathological patterns of lung injury in severe COVID-19
Pulmonary involvement in COVID-19 is characterized pathologically by diffuse alveolar damage (DAD) and thrombosis, leading to the clinical picture of Acute Respiratory Distress Syndrome. The direct action of S...
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Article
Open AccessCorrection to: Structural alterations and markers of endothelial activation in pulmonary and bronchial arteries in fatal asthma
An amendment to this paper has been published and can be accessed via the original article.
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Article
Open AccessNrf2 positively regulates autophagy antioxidant response in human bronchial epithelial cells exposed to diesel exhaust particles
Diesel exhaust particles (DEP) are known to generate reactive oxygen species in the respiratory system, triggering cells to activate antioxidant defence mechanisms, such as Keap1-Nrf2 signalling and autophagy....
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Chapter
Urban Agriculture and the Battle for History in Melbourne and São Paulo
Urban agriculture is booming around the world, and has become a marketed commodity in cities as disparate as Melbourne and São Paulo. Real estate developers, for instance, increasingly offer luxury apartments ...
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Article
Open AccessStructural alterations and markers of endothelial activation in pulmonary and bronchial arteries in fatal asthma
There is interest in better understanding vessel pathology in asthma, given the findings of loss of peripheral vasculature associated with disease severity by imaging and altered markers of endothelial activat...
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Article
Open AccessSevere pulmonary disease in an adult primary ciliary dyskinesia population in Brazil
Primary Ciliary Dyskinesia (PCD) is underdiagnosed in Brazil. We enrolled patients from an adult service of Bronchiectasis over a two-year period in a cross-sectional study. The inclusion criteria were lateral...
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Article
Effects of diode laser setting for laryngeal surgery in a rabbit model
To study the damaging effect of different diode laser settings on vocal folds 7 days after injury in a rabbit model.
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Article
Open AccessThe Th17/Treg Cytokine Imbalance in Chronic Obstructive Pulmonary Disease Exacerbation in an Animal Model of Cigarette Smoke Exposure and Lipopolysaccharide Challenge Association
We proposed an experimental model to verify the Th17/Treg cytokine imbalance in COPD exacerbation. Forty C57BL/6 mice were exposed to room air or cigarette smoke (CS) (12 ± 1 cigarettes, twice a day, 30 min/ex...
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Article
Open AccessPulmonary interstitial emphysema in fatal asthma: case report and histopathological review
Mortality related to asthma has decreased worldwide since the introduction of inhaled corticosteroid therapy in the past decades. However, there are still some asthma fatalities identified mainly in population...
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Chapter
Four Years of Experience with the Sao Paulo University Medical School Community Garden
The School of Medicine, Sao Paulo University Community Garden (FMUSP Community Garden), formed in June 2013, occupies an area of 520 m2. In the concreted area, vegetables and herbs are grown in large vessels ( ...
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Chapter
14 Years of History on Sustainability: Waste Management FMUSP/IMT/SVOC
High regulation in environmental protection and sustainability was established in Brazil around 2003. From that time, the board of directors of the Faculty of Medicine, Tropical Medicine Institute, Death Verif...
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Article
Open AccessA Potent Tartrate Resistant Acid Phosphatase Inhibitor to Study the Function of TRAP in Alveolar Macrophages
The enzyme tartrate resistant acid phosphatase (TRAP, two isoforms 5a and 5b) is highly expressed in alveolar macrophages, but its function there is unclear and potent selective inhibitors of TRAP are required...
