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Article
Open AccessGWAS for systemic sclerosis identifies six novel susceptibility loci including one in the Fcγ receptor region
Here we report the largest Asian genome-wide association study (GWAS) for systemic sclerosis performed to date, based on data from Japanese subjects and comprising of 1428 cases and 112,599 controls. The lead ...
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Article
Open AccessEffect of combined treatment with bisphosphonate and vitamin D on atherosclerosis in patients with systemic lupus erythematosus: a propensity score-based analysis
Premature atherosclerosis is one of the major complications of systemic lupus erythematosus (SLE). Recently, the biological linkage between atherosclerosis and osteoporosis has garnered much attention. The aim...
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Article
Effectiveness of a Medical English Course on Communication Abilities of Graduate Medical Students
Communication proficiency is essential in medicine, and English is an important communication tool. Teaching, learning, and develo** communicative competence in English are becoming a prominent part of educa...
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Article
Comparative analysis of different enzyme immunoassays for assessment of phosphatidylserine-dependent antiprothrombin antibodies
Phosphatidylserine-dependent antiprothrombin antibodies (aPS/PT) were strongly correlated with the presence of lupus anticoagulant showing a high specificity for the diagnosis of antiphospholipid syndrome. How...
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Article
Phospholipid scramblase 1 expression is enhanced in patients with antiphospholipid syndrome
Thrombus formation is the key event of vascular manifestations in antiphospholipid syndrome (APS). Phosphatidylserine (PS) is normally sequestered in the inner leaflet of cell membranes. Externalization of PS ...
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Article
Open AccessAberrant splicing of the hRasGRP4 transcript and decreased levels of this signaling protein in the peripheral blood mononuclear cells in a subset of patients with rheumatoid arthritis
An unidentified population of peripheral blood mononuclear cells (PBMCs) express Ras guanine nucleotide releasing protein 4 (RasGRP4). The aim of our study was to identify the cells in human blood that express...
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Article
Clinical features of reversible posterior leukoencephalopathy syndrome in patients with systemic lupus erythematosus
To characterize reversible posterior leukoencephalopathy syndrome (RPLS) in systemic lupus erythematosus (SLE) in terms of treatments for resolution and its clinical course, we reviewed 28 cases of RPLS in SLE...
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Article
Polymyalgia rheumatica as the manifestation of unclassified aortitis
Polymyalgia rheumatica (PMR) frequently occurs with giant cell arteritis (GCA). We report here two cases of PMR with aortitis in the absence of diminished pulse and manifestations related to GCA. Contrasted CT...
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Article
Abacterial prostatitis and primary biliary cirrhosis with SjÖgren’s syndrome
In patients with SjÖgren’s syndrome (SS), the salivary and lacrimal glands are often affected, although other epithelial tissues can become inflamed. Here, we report the first case of abacterial prostatitis in...